Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 12/20 | 1.00 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.71 |
| ▸ | GLA | P06280 | 2/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | ATM | Q13315 | 1/20 | 0.70 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.70 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12493661 | 0.91 | PDE5A (1.00) | PDE5ANR3C2L3MBTL1GLAPOLB | |
| SCHEMBL11121023 | 0.89 | PDE5A (0.91) | PDE5ANR3C2L3MBTL1GLAPOLB | |
| SCHEMBL11121205 | 0.89 | PDE5A (0.91) | PDE5ANR3C2L3MBTL1GLAPOLB | |
| SCHEMBL11119541 | 0.89 | PDE5A (0.91) | PDE5ANR3C2L3MBTL1GLAPOLB | |
| SCHEMBL12494300 | 0.87 | PDE5A (1.00) | PDE5ANR3C2L3MBTL1GLAPOLB | |
| SCHEMBL12492697 | 0.84 | PDE5A (1.00) | PDE5ANR3C2L3MBTL1GLAPOLB | |
| SCHEMBL9626269 | 0.83 | PDE5A (0.71) | PDE5AL3MBTL1GLAPOLBATM | |
| SCHEMBL18826382 | 0.82 | L3MBTL1 (0.84) | PDE5AL3MBTL1GLAATMPTGS2 | |
| SCHEMBL15301136 | 0.82 | KDM4E (0.88) | PDE5ANR3C2L3MBTL1GLAPOLB | |
| SCHEMBL12495092 | 0.81 | PDE5A (1.00) | PDE5ANR3C2L3MBTL1GLAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9388139-B2 | Derivatives of celeboxib, use thereof and preparation thereof | GERMAN UNIVERSITY (EG) | 2016-07-12 | — | — | US | disclosed |
| US-9388139-B2 | Derivatives of celeboxib, use thereof and preparation thereof | GERMAN UNIVERSITY (EG) | 2016-07-12 | — | — | US | disclosed |
| US-20140171477-A1 | DERIVATIVES OF CELEBOXIB, USE THEREOF AND PREPARATION THEREOF | SOUTHERN RESEARCH INSTITUTE | 2014-06-19 | — | — | US | disclosed |
| US-20140171477-A1 | DERIVATIVES OF CELEBOXIB, USE THEREOF AND PREPARATION THEREOF | SOUTHERN RESEARCH INSTITUTE | 2014-06-19 | — | — | US | disclosed |
| WO-2012125884-A1 | DERIVATIVES OF CELECOXIB, USE THEREOF AND PREPARATION THEREOF | SOUTHERN RESEARCH INSTITUTE (US) | 2012-09-20 | — | — | WO | disclosed |
| WO-2012125884-A1 | DERIVATIVES OF CELECOXIB, USE THEREOF AND PREPARATION THEREOF | SOUTHERN RESEARCH INSTITUTE (US) | 2012-09-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140171477-A1 | DERIVATIVES OF CELEBOXIB, USE THEREOF AND PREPARATION THEREOF | PDE5A, PDE3A, PDE3B | PDE5A 1/4885NR3C2 373/4885L3MBTL1 2528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.