Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 2/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 2/20 | 0.31 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.31 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.31 |
| ▸ | TDO2 | P48775 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.30 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12497694 | 0.77 | BRAF (0.47) | EGFRBRAF | |
| SCHEMBL2074475 | 0.73 | MAP3K8 (0.40) | GAAGRM5ALDH1A1CYP3A4 | |
| SCHEMBL12497631 | 0.72 | LRRK2 (0.49) | EGFRPIK3CDPIK3CACSF1RBRAF | |
| SCHEMBL15825796 | 0.70 | EGFR (1.00) | EGFRPIK3CDPIK3CAFGFR4TDO2 | |
| SCHEMBL2076283 | 0.66 | ALDH1A1 (0.44) | GAAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL30986042 | 0.66 | ALDH1A1 (0.44) | GAAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL15824972 | 0.65 | EGFR (0.71) | EGFRPIK3CDPIK3CAFGFR4TDO2 | |
| SCHEMBL30853054 | 0.64 | EGFR (0.55) | EGFRPIK3CDPIK3CAFGFR4TDO2 | |
| SCHEMBL3393275 | 0.64 | EGFR (0.55) | EGFRPIK3CDPIK3CAFGFR4TDO2 | |
| SCHEMBL30618089 | 0.64 | EGFR (0.55) | EGFRPIK3CDPIK3CAFGFR4TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012118492-A1 | HETEROCYCLIC SULFONAMIDES AS RAF INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2012-09-07 | — | — | WO | disclosed |