Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 4/20 | 0.35 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | HTR2B | P41595 | 3/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20432698 | 0.81 | HTR2C (0.50) | ALDH1A1HTR2CHTR2AHTR2BSIGMAR1 | |
| SCHEMBL17086789 | 0.81 | HTR2C (0.50) | ALDH1A1HTR2CHTR2AHTR2BSIGMAR1 | |
| SCHEMBL20432699 | 0.81 | HTR2C (0.50) | ALDH1A1HTR2CHTR2AHTR2BSIGMAR1 | |
| SCHEMBL1310132 | 0.81 | HTR2C (0.50) | ALDH1A1HTR2CHTR2AHTR2BSIGMAR1 | |
| SCHEMBL1310133 | 0.81 | HTR2C (0.50) | ALDH1A1HTR2CHTR2AHTR2BSIGMAR1 | |
| Hydrochloric Acid SCHEMBL3155670 | 0.80 | CHRM2 (0.53) | ALDH1A1HTR2CHTR2AHTR2BSIGMAR1 | |
| SCHEMBL29147689 | 0.80 | ALDH1A1 (0.42) | ALDH1A1KDM4ESIGMAR1HPGDPOLB | |
| Hydrochloric Acid SCHEMBL3155675 | 0.80 | CHRM2 (0.53) | ALDH1A1HTR2CHTR2AHTR2BSIGMAR1 | |
| SCHEMBL1427504 | 0.80 | ALDH1A1 (0.42) | ALDH1A1KDM4ESIGMAR1HPGDPOLB | |
| SCHEMBL12499953 | 0.79 | KDM4E (0.40) | ALDH1A1KDM4ECYP19A1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3826724-B1 | NOVEL PIPERAZINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | HOFFMANN LA ROCHE (CH) | 2022-10-05 | — | — | EP | disclosed |
| EP-3826724-A1 | NOVEL PIPERAZINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2021-06-02 | — | — | EP | disclosed |
| CN-112584903-A | Novel piperazine compounds for the treatment of autoimmune diseases | 豪夫迈·罗氏有限公司 | 2021-03-30 | — | — | CN | disclosed |
| WO-2020020800-A1 | NOVEL PIPERAZINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2020-01-30 | — | — | WO | disclosed |
| WO-2020020800-A1 | NOVEL PIPERAZINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2020-01-30 | — | — | WO | disclosed |
| WO-2012048411-A1 | PLK-4 INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2012-04-19 | — | — | WO | disclosed |