Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3165429 | 0.81 | MC4R (0.48) | ACHE | |
| SCHEMBL3165425 | 0.81 | MC4R (0.48) | ACHE | |
| SCHEMBL1427504 | 0.80 | ALDH1A1 (0.42) | KDM4EALDH1A1HRH3L3MBTL1BCHE | |
| SCHEMBL29147689 | 0.80 | ALDH1A1 (0.42) | KDM4EALDH1A1HRH3L3MBTL1BCHE | |
| SCHEMBL12499770 | 0.79 | ALDH1A1 (0.40) | KDM4EALDH1A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL28248487 | 0.78 | SIGMAR1 (0.44) | KDM4EALDH1A1HRH3RORC | |
| SCHEMBL12500077 | 0.75 | HRH3 (0.47) | KDM4EALDH1A1HRH3HRH4BCHE | |
| SCHEMBL20432782 | 0.70 | HDAC1 (0.41) | KDM4EALDH1A1HDAC1HDAC6L3MBTL1 | |
| SCHEMBL20153149 | 0.70 | RET (0.46) | HRH3CYP11B1 | |
| SCHEMBL16589590 | 0.70 | SIGMAR1 (0.45) | KDM4EALDH1A1HRH3HRH4L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012048411-A1 | PLK-4 INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2012-04-19 | — | — | WO | disclosed |