Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 3/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | EP300 | Q09472 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL459193 | 0.79 | TDO2 (0.53) | TDO2TSHRIDO1NR4A2MAPT | |
| SCHEMBL31158048 | 0.79 | TDO2 (0.53) | TDO2TSHRIDO1NR4A2MAPT | |
| SCHEMBL25996747 | 0.74 | IDO1 (0.49) | TDO2TSHRIDO1NR4A2MEN1 | |
| SCHEMBL2924367 | 0.73 | TSHR (0.55) | TDO2TSHRIDO1MEN1KMT2A | |
| SCHEMBL4717977 | 0.73 | TSHR (0.47) | TSHR | |
| SCHEMBL2592578 | 0.73 | NR4A2 (0.48) | TSHRIDO1NR4A2MEN1KMT2A | |
| SCHEMBL5437444 | 0.70 | METAP2 (0.52) | TDO2TSHRIDO1 | |
| SCHEMBL2594220 | 0.69 | NOS1 (0.44) | TDO2TSHRIDO1MEN1KMT2A | |
| SCHEMBL3949930 | 0.69 | PIK3CD (0.53) | TSHRIDO1NR4A2MAPT | |
| SCHEMBL31179362 | 0.68 | TSHR (0.51) | TDO2TSHRNR4A2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681216-A2 | SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS | Epizyme, Inc. (US) | 2014-01-08 | — | — | EP | disclosed |
| WO-2012118812-A2 | SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS | Epizyme, Inc. (US) | 2012-09-07 | — | — | WO | disclosed |