Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HTR6 | P50406 | 7/20 | 0.40 |
| ▸ | WNT1 | P04628 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3509001 | 0.81 | CYP2C19 (0.51) | PDPK1HTR6WNT1GSK3BDYRK1A | |
| SCHEMBL12501057 | 0.75 | PDPK1 (1.00) | PDPK1 | |
| SCHEMBL2724221 | 0.71 | BRD4 (0.62) | PDPK1HTR6WNT1GSK3BDYRK1A | |
| SCHEMBL3506020 | 0.71 | PDPK1 (0.54) | PDPK1HTR6WNT1GSK3BDYRK1A | |
| SCHEMBL17759254 | 0.71 | MET (0.51) | PDPK1HTR6MAPK1AURKBMET | |
| SCHEMBL17742865 | 0.70 | PDPK1 (0.77) | PDPK1HTR6DYRK1ACCNCCDK8 | |
| SCHEMBL2750994 | 0.69 | PDPK1 (0.54) | PDPK1HTR6FGFR1MET | |
| SCHEMBL9280138 | 0.69 | PDPK1 (0.49) | PDPK1HTR6WNT1GSK3BDYRK1A | |
| SCHEMBL21404588 | 0.68 | HTR6 (0.49) | PDPK1HTR6WNT1GSK3BDYRK1A | |
| SCHEMBL30878062 | 0.68 | HTR6 (0.49) | PDPK1HTR6WNT1GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2670748-A2 | 7-AZAINDOLE DERIVATIVES | Merck Patent GmbH (DE) | 2013-12-11 | — | — | EP | disclosed |
| WO-2012104007-A2 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-08-09 | — | — | WO | disclosed |