Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.77 |
| ▸ | HTR6 | P50406 | 3/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | HAT1 | O14929 | 2/20 | 0.38 |
| ▸ | EP300 | Q09472 | 2/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17738792 | 0.91 | PDPK1 (0.63) | PDPK1HTR6AXLCREBBPMET | |
| SCHEMBL12501057 | 0.87 | PDPK1 (1.00) | PDPK1TGFBR1IKBKETBK1ALK | |
| SCHEMBL15397145 | 0.78 | PDPK1 (0.84) | PDPK1HTR6ALK | |
| SCHEMBL12501042 | 0.74 | PDPK1 (0.68) | PDPK1HTR6METPIM1TGFBR1 | |
| SCHEMBL12501064 | 0.70 | PDPK1 (0.60) | PDPK1HTR6DYRK1AMETCCNC | |
| SCHEMBL12501099 | 0.69 | HTR6 (0.54) | PDPK1HTR6PIM1TGFBR1IKBKE | |
| SCHEMBL16698105 | 0.69 | PDPK1 (0.54) | PDPK1HTR6BRD4CA12CA9 | |
| SCHEMBL12501063 | 0.68 | PDPK1 (0.69) | PDPK1DYRK1ATGFBR1IKBKETBK1 | |
| SCHEMBL13051118 | 0.67 | HTR6 (0.52) | PDPK1HTR6DYRK1AMETCA12 | |
| SCHEMBL22777950 | 0.66 | PDPK1 (0.49) | PDPK1HTR6BRD4CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160130269-A1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160130269-A1 | 7-AZAINDOLE DERIVATIVES | PDK1, PDK2, PDK3 | PDPK1 12/4885HTR6 3525/4885AXL 3557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.