Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LATS1 | O95835 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | GLA | P06280 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22418422 | 0.82 | SIRT3 (0.33) | ALDH1A1KDM4EGLAGAAKMT2A | |
| SCHEMBL3250625 | 0.80 | MAPT (0.40) | ALDH1A1KDM4EGLAGAAHTT | |
| SCHEMBL18328043 | 0.79 | CYP1A2 (0.34) | KDM4EADORA3 | |
| SCHEMBL26124470 | 0.72 | GSK3B (0.36) | KDM4EHTTHSD17B10KMT2A | |
| SCHEMBL4654925 | 0.71 | ALDH1A1 (0.32) | ALDH1A1KDM4EGAAKMT2A | |
| SCHEMBL28322925 | 0.69 | — | — | |
| SCHEMBL18327740 | 0.68 | — | — | |
| SCHEMBL12324878 | 0.67 | — | — | |
| SCHEMBL12503258 | 0.66 | IGF1R (0.42) | LATS1ALDH1A1KDM4EGLAGAA | |
| SCHEMBL13604128 | 0.66 | NAMPT (0.42) | LATS1ALDH1A1KDM4EGLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2670750-A1 | NAPHTHYRIDINE DERIVATIVES AS INHIBITORS OF HYPOXIA INDUCIBLE FACTOR (HIF) HYDROXYLASE | Fibrogen, Inc. (US) | 2013-12-11 | — | — | EP | disclosed |
| WO-2012106472-A1 | NAPHTHYRIDINE DERIVATIVES AS INHIBITORS OF HYPOXIA INDUCIBLE FACTOR (HIF) HYDROXYLASE | FIBROGEN, INC. (US) | 2012-08-09 | — | — | WO | disclosed |