Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 14/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 14/20 | 0.55 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.50 |
| ▸ | SGK2 | Q9HBY8 | 3/20 | 0.50 |
| ▸ | PRKACA | P17612 | 2/20 | 0.50 |
| ▸ | PRKX | P51817 | 2/20 | 0.50 |
| ▸ | PRKG2 | Q13237 | 2/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.50 |
| ▸ | CLK2 | P49760 | 2/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.50 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.50 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.50 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.50 |
| ▸ | PRKCG | P05129 | 1/20 | 0.50 |
| ▸ | MARK3 | P27448 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | AKT1 | P31749 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627181 | 0.83 | ROCK2 (0.54) | ROCK2ROCK1RPS6KB1CLK4SGK2 | |
| SCHEMBL6312939 | 0.72 | ROCK1 (0.77) | ROCK2ROCK1RPS6KB1CLK4SGK2 | |
| SCHEMBL26715302 | 0.72 | ROCK2 (0.65) | ROCK2ROCK1RPS6KB1CLK4SGK2 | |
| SCHEMBL12059777 | 0.72 | ROCK2 (0.70) | ROCK2ROCK1RPS6KB1CLK4SGK2 | |
| SCHEMBL15146104 | 0.71 | ROCK2 (1.00) | ROCK2ROCK1RPS6KB1CLK4SGK2 | |
| SCHEMBL15147870 | 0.71 | ROCK2 (1.00) | ROCK2ROCK1RPS6KB1CLK4CLK2 | |
| SCHEMBL4577230 | 0.71 | ROCK2 (0.67) | ROCK2ROCK1RPS6KB1CLK4SGK2 | |
| SCHEMBL24033483 | 0.71 | ROCK2 (0.65) | ROCK2ROCK1RPS6KB1CLK4SGK2 | |
| SCHEMBL22125279 | 0.71 | ROCK2 (0.66) | ROCK2ROCK1RPS6KB1CLK4SGK2 | |
| SCHEMBL30665086 | 0.71 | ROCK2 (0.65) | ROCK2ROCK1RPS6KB1CLK4SGK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020080-A2 | LIGANDS FOR ANTIBODY AND Fc-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMATOGRAPHY II | GRAFFINITY PHARMACEUTICALS GMBH (DE) | 2012-02-16 | — | — | WO | disclosed |