Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 14/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 14/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.48 |
| ▸ | SGK2 | Q9HBY8 | 3/20 | 0.48 |
| ▸ | PRKACA | P17612 | 2/20 | 0.48 |
| ▸ | PRKX | P51817 | 2/20 | 0.48 |
| ▸ | PRKG2 | Q13237 | 2/20 | 0.48 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.47 |
| ▸ | CLK2 | P49760 | 2/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.47 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.47 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.47 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12503547 | 0.83 | ROCK2 (0.55) | ROCK2ROCK1NPC1RAB9AJAK2 | |
| SCHEMBL623932 | 0.76 | RAB9A (0.59) | NPC1RAB9A | |
| SCHEMBL10083553 | 0.75 | KDM4E (0.51) | — | |
| SCHEMBL623623 | 0.74 | KDR (0.53) | NPC1RAB9AMAPK1 | |
| SCHEMBL625959 | 0.73 | HDAC6 (0.46) | NPC1RAB9ACSNK1DCSNK2A1 | |
| SCHEMBL624357 | 0.72 | RAB9A (0.51) | NPC1RAB9A | |
| SCHEMBL625899 | 0.72 | MAPT (0.46) | NPC1RAB9AMAPK1TMIGD3ADORA1 | |
| SCHEMBL26715302 | 0.72 | ROCK2 (0.65) | ROCK2ROCK1NPC1RAB9ARPS6KB1 | |
| SCHEMBL623924 | 0.71 | ABL1 (0.56) | ROCK2MAPK1PRKCD | |
| SCHEMBL12059777 | 0.71 | ROCK2 (0.70) | ROCK2ROCK1NPC1RAB9AJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020080-A2 | LIGANDS FOR ANTIBODY AND Fc-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMATOGRAPHY II | GRAFFINITY PHARMACEUTICALS GMBH (DE) | 2012-02-16 | — | — | WO | disclosed |
| WO-2012020080-A2 | LIGANDS FOR ANTIBODY AND Fc-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMATOGRAPHY II | GRAFFINITY PHARMACEUTICALS GMBH (DE) | 2012-02-16 | — | — | WO | disclosed |