Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.67 |
| ▸ | RAB9A | P51151 | 10/20 | 0.67 |
| ▸ | MTOR | P42345 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.52 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.50 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.49 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.49 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1251631 | 0.84 | NPC1 (0.56) | NPC1RAB9AMTORCYP3A4ADORA3 | |
| SCHEMBL3770533 | 0.83 | NPC1 (0.71) | NPC1RAB9AMTORCYP3A4ADORA3 | |
| SCHEMBL3770530 | 0.81 | NPC1 (0.71) | NPC1RAB9AMTORCYP3A4ADORA3 | |
| SCHEMBL6257291 | 0.81 | NPC1 (1.00) | NPC1RAB9AMTORADORA3ADORA2A | |
| SCHEMBL12204397 | 0.80 | NPC1 (1.00) | NPC1RAB9AMTORADORA3ADORA2A | |
| SCHEMBL5091480 | 0.78 | NPC1 (0.77) | NPC1RAB9AMTORCYP3A4ADORA3 | |
| SCHEMBL15931641 | 0.78 | NPC1 (1.00) | NPC1RAB9AMTORCYP3A4ADORA3 | |
| SCHEMBL3764441 | 0.77 | RAB9A (0.78) | NPC1RAB9AMTORKMT2AMEN1 | |
| SCHEMBL19616650 | 0.76 | NPC1 (0.74) | NPC1RAB9AMTORCYP3A4ADORA3 | |
| SCHEMBL2947068 | 0.76 | GRM5 (0.68) | NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074089-B1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2013-09-18 | — | — | EP | disclosed |
| US-8222248-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-07-17 | — | — | US | disclosed |
| US-20110046133-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2011-02-24 | — | — | US | disclosed |
| EP-2074089-A2 | ORGANIC COMPOUNDS | Novartis AG (CH) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008048991-A2 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2008-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046133-A1 | ORGANIC COMPOUNDS | DGAT1, DGAT2, SOAT1 | NPC1 32/4885RAB9A 1888/4885MTOR 3883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.