Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | PREP | P48147 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12019238 | 0.92 | KMT2A (0.48) | PSMB5KMT2ATRPA1SMN1; SMN2HSD17B10 | |
| SCHEMBL18101858 | 0.85 | KMT2A (0.40) | PSMB5KMT2ATRPA1SMN1; SMN2HSD17B10 | |
| SCHEMBL13574437 | 0.82 | KMT2A (0.41) | PSMB5KMT2ATRPA1SMN1; SMN2HSD17B10 | |
| SCHEMBL25781893 | 0.82 | KMT2A (0.41) | PSMB5KMT2ATRPA1SMN1; SMN2HSD17B10 | |
| SCHEMBL19302833 | 0.82 | EPHX1 (0.57) | PSMB5SMN1; SMN2HSD17B10EPHX1NAAA | |
| SCHEMBL5855995 | 0.82 | EPHX1 (0.57) | PSMB5SMN1; SMN2HSD17B10EPHX1NAAA | |
| SCHEMBL2576766 | 0.81 | KMT2A (0.44) | PSMB5KMT2ACHRNB2CHRNA4CHRNA7 | |
| SCHEMBL22697173 | 0.81 | OPRM1 (0.42) | PSMB5KMT2ATRPA1SMN1; SMN2HSD17B10 | |
| SCHEMBL2576767 | 0.81 | KMT2A (0.44) | PSMB5KMT2ACHRNB2CHRNA4CHRNA7 | |
| SCHEMBL5909567 | 0.80 | CHRNB2 (0.50) | KMT2ACHRNB2CHRNA4CHRNA7SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110171171-A1 | BRIDGED SECONDARY AMINES AND USE THEREOF AS IAP BIR DOMAIN BINDING COMPOUNDS | AEGERA THERAPEUTICS, INC. (CA) | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110171171-A1 | BRIDGED SECONDARY AMINES AND USE THEREOF AS IAP BIR DOMAIN BINDING COMPOUNDS | BIRC5, BIRC2, BIRC7 | PSMB5 994/4885KMT2A 3329/4885CHRNB2 3988/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.