Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 5/20 | 0.38 |
| ▸ | KDR | P35968 | 4/20 | 0.37 |
| ▸ | CLK2 | P49760 | 2/20 | 0.34 |
| ▸ | CLK3 | P49761 | 2/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.33 |
| ▸ | MAPKAPK3 | Q16644 | 3/20 | 0.33 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.33 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | WNT1 | P04628 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13946440 | 0.90 | KDR (0.43) | DYRK1AGSK3BKDRFGFR1PDE10A | |
| SCHEMBL13183133 | 0.80 | HTR1D (0.43) | DYRK1AJAK2CLK2CLK3MAPK1 | |
| SCHEMBL1176377 | 0.79 | PRKAG1 (0.55) | DYRK1AGSK3BCLK2CLK3HDAC4 | |
| SCHEMBL13183062 | 0.73 | CHEK1 (0.47) | JAK2MAPK1MAP2K4MAPKAPK3MAPK6 | |
| SCHEMBL5953047 | 0.73 | MAP2K4 (0.49) | MAPK1MAP2K4MAPKAPK3MAPK6MAPKAPK2 | |
| SCHEMBL13183156 | 0.72 | JAK2 (0.61) | DYRK1AGSK3BJAK2CLK2CLK3 | |
| SCHEMBL17860612 | 0.72 | JAK2 (0.68) | DYRK1AGSK3BJAK2 | |
| SCHEMBL11913101 | 0.71 | JAK2 (0.46) | DYRK1AJAK2KDRCLK2MAPK1 | |
| SCHEMBL1176331 | 0.71 | GSK3B (0.44) | DYRK1AGSK3BMMP12HDAC4 | |
| SCHEMBL13183137 | 0.71 | JAK2 (0.44) | DYRK1AGSK3BJAK2KDRCLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110178075-A1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | XIE WENGE | 2011-07-21 | — | — | US | disclosed |
| US-20090325939-A1 | 1H-INDAZOLES, BENZOTHIAZOLES, 1,2-BENZOISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND CHROMONES AND PREPARATION AND USES THEREOF | XIE WENGE | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325939-A1 | 1H-INDAZOLES, BENZOTHIAZOLES, 1,2-BENZOISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND CHROMONES AND PREPARATION AND USES THEREOF | CHRNA7, CHRNA1, CHRNA5 | DYRK1A 2107/4885GSK3B 1110/4885JAK2 2400/4885 |
| US-20110178075-A1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | CHRNA7, CHRNA5, CHRNA2 | DYRK1A 1558/4885GSK3B 920/4885JAK2 1993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.