Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 0.38 |
| ▸ | JAK3 | P52333 | 4/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | DHX9 | Q08211 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL165695 | 0.92 | PARP1 (0.40) | PARP1JAK3JAK1GPR142MET | |
| SCHEMBL2265122 | 0.91 | PARP1 (0.38) | PARP1JAK3JAK1GPR142MET | |
| SCHEMBL2365347 | 0.90 | PARP1 (0.47) | PARP1JAK3MET | |
| SCHEMBL13465733 | 0.90 | MET (0.40) | PARP1JAK3JAK1MET | |
| SCHEMBL13274893 | 0.89 | HTR1A (0.44) | PARP1MET | |
| SCHEMBL2361582 | 0.89 | PARP1 (0.49) | PARP1JAK3JAK2 | |
| SCHEMBL2271983 | 0.89 | PARP1 (0.41) | PARP1JAK3JAK1METAURKA | |
| SCHEMBL13465435 | 0.88 | PARP1 (0.49) | PARP1JAK3JAK1METJAK2 | |
| SCHEMBL255442 | 0.87 | RORC (0.40) | PARP1AURKA | |
| SCHEMBL2269942 | 0.87 | SMN1; SMN2 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011084402-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |