Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | WDR5 | P61964 | 1/20 | 0.40 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.35 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.33 |
| ▸ | CES1 | P23141 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30032917 | 1.00 | ALDH1A1 (0.41) | ALDH1A1CYP2A6TDP1HSD17B10CYP3A4 | |
| Hydrochloric Acid SCHEMBL30500984 | 0.96 | ALDH1A1 (0.41) | ALDH1A1CYP2A6TDP1HSD17B10CYP3A4 | |
| Hydrochloric Acid SCHEMBL19899204 | 0.96 | ALDH1A1 (0.41) | ALDH1A1CYP2A6TDP1HSD17B10CYP3A4 | |
| Hydrochloric Acid SCHEMBL18890419 | 0.96 | ALDH1A1 (0.41) | ALDH1A1CYP2A6TDP1HSD17B10CYP3A4 | |
| Hydrochloric Acid SCHEMBL7943444 | 0.96 | ALDH1A1 (0.41) | ALDH1A1CYP2A6TDP1HSD17B10CYP3A4 | |
| SCHEMBL29350037 | 0.96 | ALDH1A1 (0.44) | ALDH1A1CYP2A6TDP1HSD17B10CYP3A4 | |
| SCHEMBL29496111 | 0.96 | ALDH1A1 (0.44) | ALDH1A1CYP2A6TDP1HSD17B10CYP3A4 | |
| SCHEMBL146878 | 0.96 | ALDH1A1 (0.44) | ALDH1A1CYP2A6TDP1HSD17B10CYP3A4 | |
| SCHEMBL5107 | 0.96 | ALDH1A1 (0.44) | ALDH1A1CYP2A6TDP1HSD17B10CYP3A4 | |
| SCHEMBL10323632 | 0.96 | ALDH1A1 (0.44) | ALDH1A1CYP2A6TDP1HSD17B10CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3589615-B1 | PYRIDYL DERIVATIVES AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2021-11-10 | — | — | EP | disclosed |
| US-10934272-B2 | Pyridyl derivatives as bromodomain inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) | 2021-03-02 | — | — | US | disclosed |
| US-10849897-B2 | Pyridyl derivatives as bromodomain inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2020-12-01 | — | — | US | disclosed |
| US-10844015-B2 | Pyridine dicarboxamide derivatives as bromodomain inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) | 2020-11-24 | — | — | US | disclosed |
| EP-3231798-B1 | THIAZOLE INTERMEDIATES USEFUL IN THE PREPARATION OF RAF KINASE INHIBITORS | SUNESIS PHARMACEUTICALS INC (US) | 2019-10-09 | — | — | EP | disclosed |
| US-20190202786-A1 | PYRIDINE DICARBOXAMIDE DERIVATIVES AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) | 2019-07-04 | — | — | US | disclosed |
| US-20190119248-A1 | PYRIDYL DERIVATIVES AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) | 2019-04-25 | — | — | US | disclosed |
| US-10028962-B2 | 2-amino-6-methy1-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl-1,3-thiazol-4-yl amides | PFIZER INC. (US) | 2018-07-24 | — | — | US | disclosed |
| US-9920048-B2 | Substituted pyrimidines for inhibiting Raf kinase activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2018-03-20 | — | — | US | disclosed |
| US-20170304312-A1 | 2-Amino-6-Methyl-4,4a,5,6-Tetrahydropyrano[3,4-d][1,3]Thiazin-8a(8H)-yl-1,3-Thiazol-4-yl Amides | PFIZER INC. (US) | 2017-10-26 | — | — | US | disclosed |
| US-6613717-B1 | Phosphoric benzoyl derivatives and their use as herbicides | BASF AKTIENGESELLSCHAFT (DE) | 2003-09-02 | — | — | US | disclosed |
| US-6613719-B1 | Agricultural herbicides; acylation | BASF AKTIENGESELLSCHAFT (DE) | 2003-09-02 | — | — | US | disclosed |
| US-6599860-B1 | Methods for controlling undesirable vegetation using the compounds | BASF AKTIENGESELLSCHAFT (DE) | 2003-07-29 | — | — | US | disclosed |
| US-20030092576-A1 | Herbicidal 3-( 4,5 dihydroisoxazole- 3 yl) substituted benzoycyclohexenone derivatives | BASF AKTIENGESELLSCHAFT (DE) | 2003-05-15 | — | — | US | disclosed |
| US-20030028033-A1 | Process and novel intermediates for preparing isoxazolin-3-ylacyl benzenes | DEYN WOLFGANG VON (DE) | 2003-02-06 | — | — | US | disclosed |
| US-6506708-B1 | Herbicidal activity of the 3-(heterocyclyl)benzoylpyrazole derivatives of the formula I was demonstrated | BASF AKTIENGESELLSCHAFT (DE) | 2003-01-14 | — | — | US | disclosed |
| US-6469176-B1 | CROP PROTECTION COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2002-10-22 | — | — | US | disclosed |
| US-6265506-B1 | AMORPHOUS COPOLYMERS | THE B. F. GOODRICH COMPANY | 2001-07-24 | — | — | US | disclosed |
| EP-0988331-A1 | METHOD FOR THE PREPARATION OF COPOLYMERS OF ETHYLENE/NORBORNENE-TYPE MONOMERS WITH CATIONIC PALLADIUM CATALYSTS | THE B.F. GOODRICH COMPANY (US) | 2000-03-29 | — | — | EP | disclosed |
| WO-1998056839-A1 | METHOD FOR THE PREPARATION OF COPOLYMERS OF ETHYLENE/NORBORNENE-TYPE MONOMERS WITH CATIONIC PALLADIUM CATALYSTS | THE B.F. GOODRICH COMPANY (US) | 1998-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10028962-B2 | 2-amino-6-methy1-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl-1,3-thiazol-4-yl amides | TPMT, TH, MAT1A | ALDH1A1 52/4885CYP2A6 232/4885TDP1 398/4885 |
| US-10934272-B2 | Pyridyl derivatives as bromodomain inhibitors | BRD4, BRD3, BRDT | ALDH1A1 2114/4885CYP2A6 2831/4885TDP1 1681/4885 |
| US-20170304312-A1 | 2-Amino-6-Methyl-4,4a,5,6-Tetrahydropyrano[3,4-d][1,3]Thiazin-8a(8H)-yl-1,3-Thiazol-4-yl Amides | TPMT, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, UGT1A8 | ALDH1A1 198/4885CYP2A6 91/4885TDP1 338/4885 |
| US-10849897-B2 | Pyridyl derivatives as bromodomain inhibitors | BRD4, BRD3, BRPF3 | ALDH1A1 3097/4885CYP2A6 2676/4885TDP1 849/4885 |
| US-20190119248-A1 | PYRIDYL DERIVATIVES AS BROMODOMAIN INHIBITORS | BRD4, BRD3, BRDT | ALDH1A1 2114/4885CYP2A6 2831/4885TDP1 1681/4885 |
| US-20030092576-A1 | Herbicidal 3-( 4,5 dihydroisoxazole- 3 yl) substituted benzoycyclohexenone derivatives | DDT, CYP4X1, CYP8B1 | ALDH1A1 51/4885CYP2A6 383/4885TDP1 1815/4885 |
| US-20030028033-A1 | Process and novel intermediates for preparing isoxazolin-3-ylacyl benzenes | CYP2F1, CBR3, CBR1 | ALDH1A1 229/4885CYP2A6 18/4885TDP1 3979/4885 |
| US-20190202786-A1 | PYRIDINE DICARBOXAMIDE DERIVATIVES AS BROMODOMAIN INHIBITORS | BRD4, BRD3, BRPF3 | ALDH1A1 1717/4885CYP2A6 2615/4885TDP1 2150/4885 |
| US-10844015-B2 | Pyridine dicarboxamide derivatives as bromodomain inhibitors | BRD4, BRD3, BRPF3 | ALDH1A1 1717/4885CYP2A6 2615/4885TDP1 2150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.