Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | CES1 | P23141 | 6/20 | 0.52 |
| ▸ | CES2 | O00748 | 5/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KDM5A | P29375 | 3/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | KDM5C | P41229 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | PPARD | Q03181 | 3/20 | 0.40 |
| ▸ | PPARA | Q07869 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11308893 | 0.90 | ALDH1A1 (0.58) | ALDH1A1CES1CES2AKR1B1PPARG | |
| SCHEMBL2022809 | 0.90 | ALDH1A1 (0.58) | ALDH1A1CES1CES2AKR1B1PPARG | |
| SCHEMBL13715021 | 0.90 | ALDH1A1 (0.58) | ALDH1A1CES1CES2AKR1B1PPARG | |
| SCHEMBL19457415 | 0.90 | ALDH1A1 (0.58) | ALDH1A1CES1CES2AKR1B1PPARG | |
| SCHEMBL13715261 | 0.90 | ALDH1A1 (0.58) | ALDH1A1CES1CES2AKR1B1PPARG | |
| SCHEMBL13715260 | 0.90 | ALDH1A1 (0.58) | ALDH1A1CES1CES2AKR1B1PPARG | |
| SCHEMBL14533776 | 0.85 | ALDH1A1 (0.54) | ALDH1A1CES1CES2KDM5AKDM4C | |
| SCHEMBL9210592 | 0.83 | — | — | |
| SCHEMBL827843 | 0.83 | — | — | |
| SCHEMBL14032784 | 0.82 | ALDH1A1 (0.48) | ALDH1A1CES1CES2TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9085659-B2 | Polymer derivatives comprising an imide branching point | NEKTAR THERAPEUTICS (US) | 2015-07-21 | — | — | US | disclosed |
| US-20120238640-A9 | Polymer Derivatives Comprising an Imide Branching Point | NEKTAR THERAPEUTICS | 2012-09-20 | — | — | US | disclosed |
| US-20080319091-A1 | Polymer Derivatives Comprising an Imide Branching Point | NEKTAR THERAPEUTICS AL, CORPORATION | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238640-A9 | Polymer Derivatives Comprising an Imide Branching Point | INCENP, ILK, PIM3 | ALDH1A1 1949/4885CES1 2413/4885CES2 2528/4885 |
| US-20080319091-A1 | Polymer Derivatives Comprising an Imide Branching Point | INCENP, ILK, PIM3 | ALDH1A1 1949/4885CES1 2413/4885CES2 2528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.