Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.58 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.46 |
| ▸ | MET | P08581 | 3/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.46 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.45 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | GRK2 | P25098 | 1/20 | 0.43 |
| ▸ | GRK5 | P34947 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | INPPL1 | O15357 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2320474 | 0.89 | MAP4K1 (0.53) | MAP4K1ALKMETCHRNB2CHRNA4 | |
| SCHEMBL12524281 | 0.89 | MAP4K1 (0.47) | MAP4K1MET | |
| Hydrochloric Acid SCHEMBL13834975 | 0.88 | MAP4K1 (0.52) | MAP4K1ALKMETCHRNB2CHRNA4 | |
| SCHEMBL320855 | 0.83 | MAP4K1 (0.56) | MAP4K1ALKMETCHRNB2CHRNA4 | |
| SCHEMBL12495538 | 0.83 | MAP4K1 (0.49) | MAP4K1METJAK2JAK3 | |
| SCHEMBL12495426 | 0.82 | MAP4K1 (0.51) | MAP4K1ALKMETPIM1 | |
| SCHEMBL2321067 | 0.80 | INPPL1 (0.50) | MAP4K1ALKMETCHRNB2CHRNA4 | |
| SCHEMBL2324841 | 0.80 | MAP4K3 (0.47) | MAP4K1ALKMETCHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL2324061 | 0.80 | INPPL1 (0.49) | MAP4K1ALKMETCHRNB2CHRNA4 | |
| SCHEMBL12524282 | 0.79 | MET (0.49) | MAP4K1METINPPL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012119690-A1 | PYRIDO [2, 3 - B] PYRAZINE DERIVATIVES AND THEIR THERAPEUTICAL USES | MERCK PATENT GMBH (DE) | 2012-09-13 | — | — | WO | disclosed |