Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 12/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.54 |
| ▸ | PGR | P06401 | 6/20 | 0.54 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | AR | P10275 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6523590 | 0.91 | HIF1A (0.61) | LMNASMN1; SMN2HIF1ACYP3A4PGR | |
| SCHEMBL24622441 | 0.91 | HIF1A (0.61) | LMNASMN1; SMN2HIF1ACYP3A4PGR | |
| SCHEMBL2300385 | 0.91 | HIF1A (0.61) | LMNASMN1; SMN2HIF1ACYP3A4PGR | |
| SCHEMBL12528262 | 0.88 | HIF1A (0.55) | LMNASMN1; SMN2HIF1ACYP3A4PGR | |
| SCHEMBL6323672 | 0.83 | LMNA (0.82) | LMNASMN1; SMN2HIF1ACYP3A4PGR | |
| SCHEMBL6323667 | 0.83 | LMNA (0.82) | LMNASMN1; SMN2HIF1ACYP3A4PGR | |
| SCHEMBL11525651 | 0.83 | LMNA (0.82) | LMNASMN1; SMN2HIF1ACYP3A4PGR | |
| SCHEMBL14680126 | 0.79 | PGR (0.56) | LMNASMN1; SMN2HIF1ACYP3A4PGR | |
| SCHEMBL12524081 | 0.79 | PGR (0.61) | LMNASMN1; SMN2HIF1ACYP3A4PGR | |
| SCHEMBL2297384 | 0.79 | PGR (0.61) | LMNASMN1; SMN2HIF1ACYP3A4PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012123493-A2 | ISOXAZOLIDINE DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 2012-09-20 | — | — | WO | disclosed |