SCHEMBL12528322

SCHEMBL12528322

Cc1cc(C)c2nc(-c3cn(C)nc3-c3ccccc3Cl)oc(=O)c2c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ C1R P00736 3/20 0.44
▸ KLK7 P49862 3/20 0.43
▸ KLK14 Q9P0G3 3/20 0.43
▸ KLK5 Q9Y337 3/20 0.43
▸ CTSG P08311 2/20 0.43
▸ PRSS1 P07477 1/20 0.43
▸ ELANE P08246 2/20 0.41
▸ F7 P08709 1/20 0.40
▸ F3 P13726 1/20 0.40
▸ PIM1 P11309 1/20 0.40
▸ CSNK2A2 P19784 1/20 0.40
▸ CSNK2B P67870 1/20 0.40
▸ PIM3 Q86V86 1/20 0.40
▸ PIM2 Q9P1W9 1/20 0.40
▸ MEN1 O00255 3/20 0.38
▸ KMT2A Q03164 3/20 0.38
▸ MAPT P10636 2/20 0.38
▸ NPC1 O15118 1/20 0.38
▸ APEX1 P27695 1/20 0.38
▸ PIK3CD O00329 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL949951 0.92 C1R (0.44) C1RKLK7KLK14KLK5CTSG
SCHEMBL12528338 0.81 F7 (0.48) C1RKLK7KLK14KLK5CTSG
SCHEMBL12912012 0.77 C1R (0.43) C1RKLK7KLK14KLK5CTSG
SCHEMBL12528482 0.75 C1R (0.41) C1RKLK7KLK14KLK5CTSG
SCHEMBL12747248 0.74 SMN1; SMN2 (0.37) C1RELANEMEN1KMT2APIK3CD
SCHEMBL25054223 0.73 C1R (0.63) C1RKLK7KLK14KLK5CTSG
SCHEMBL951337 0.73 F7 (0.48) C1RKLK7KLK14KLK5CTSG
SCHEMBL12528680 0.72 PBRM1 (0.40) C1RELANEMEN1KMT2AMAPT
SCHEMBL12528672 0.71 PBRM1 (0.34) C1RELANEMEN1KMT2AMAPT
SCHEMBL22952937 0.71 NPC1 (0.51) ELANECSNK2A2CSNK2BMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7968573-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-06-28 — — US disclosed
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME IKEGAMI HIROSHI 2011-03-24 — — US disclosed
US-7867949-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-11 — — US disclosed
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, H1-2, H1-0 C1R 1132/4885KLK7 2386/4885KLK14 1747/4885
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same ACHE, DDT, CAT C1R 4485/4885KLK7 2138/4885KLK14 1826/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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