SCHEMBL12528338

SCHEMBL12528338

Cc1cc(C)c2nc(-c3cnn(C)c3-c3ccccc3Cl)oc(=O)c2c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ F7 P08709 1/20 0.48
▸ F3 P13726 1/20 0.48
▸ C1R P00736 4/20 0.46
▸ ELANE P08246 4/20 0.42
▸ PRMT5 O14744 1/20 0.41
▸ WDR77 Q9BQA1 1/20 0.41
▸ KLK7 P49862 3/20 0.40
▸ KLK14 Q9P0G3 3/20 0.40
▸ KLK5 Q9Y337 3/20 0.40
▸ CTSG P08311 2/20 0.40
▸ PRSS1 P07477 1/20 0.40
▸ PIM1 P11309 1/20 0.37
▸ CSNK2A2 P19784 1/20 0.37
▸ CSNK2B P67870 1/20 0.37
▸ PIM3 Q86V86 1/20 0.37
▸ PIM2 Q9P1W9 1/20 0.37
▸ APEX1 P27695 1/20 0.36
▸ HIF1A Q16665 1/20 0.36
▸ PARP1 P09874 1/20 0.36
▸ MEN1 O00255 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL951337 0.92 F7 (0.48) F7F3C1RELANEPRMT5
SCHEMBL14542329 0.88 F7 (0.47) F7F3C1RELANEPRMT5
SCHEMBL12912012 0.87 C1R (0.43) F7F3C1RELANEKLK7
SCHEMBL12528482 0.85 C1R (0.41) F7F3C1RELANEKLK7
SCHEMBL12528322 0.81 C1R (0.44) F7F3C1RELANEKLK7
SCHEMBL950651 0.79 C1R (0.43) F7F3C1RELANEKLK7
SCHEMBL13072421 0.78 C1R (0.40) F7F3C1RELANEKLK7
SCHEMBL949951 0.73 C1R (0.44) F7F3C1RELANEKLK7
SCHEMBL25054223 0.71 C1R (0.63) F7F3C1RELANEKLK7
SCHEMBL12528180 0.71 CYP17A1 (0.37) F7F3C1RELANEPARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7968573-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-06-28 — — US disclosed
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME IKEGAMI HIROSHI 2011-03-24 — — US disclosed
US-7867949-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-11 — — US disclosed
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, H1-2, H1-0 F7 2631/4885F3 1230/4885C1R 1132/4885
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same ACHE, DDT, CAT F7 3150/4885F3 3914/4885C1R 4485/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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