SCHEMBL950651

SCHEMBL950651

Cc1cc(Cl)cc2c(=O)oc(-c3cnn(C(C)(C)C)c3-c3ccccc3Cl)nc12

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ C1R P00736 7/20 0.43
▸ F7 P08709 1/20 0.41
▸ F3 P13726 1/20 0.41
▸ ELANE P08246 4/20 0.40
▸ KLK7 P49862 3/20 0.38
▸ KLK14 Q9P0G3 3/20 0.38
▸ KLK5 Q9Y337 3/20 0.38
▸ CTSG P08311 2/20 0.38
▸ PRSS1 P07477 2/20 0.38
▸ APEX1 P27695 1/20 0.37
▸ MAPT P10636 2/20 0.34
▸ MEN1 O00255 2/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ F2 P00734 1/20 0.34
▸ PLG P00747 1/20 0.34
▸ KLK1 P06870 1/20 0.34
▸ C1S P09871 1/20 0.34
▸ HTT P42858 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12912012 0.92 C1R (0.43) C1RF7F3ELANEKLK7
SCHEMBL951337 0.87 F7 (0.48) C1RF7F3ELANEKLK7
SCHEMBL13072421 0.81 C1R (0.40) C1RF7F3ELANEKLK7
SCHEMBL12528338 0.79 F7 (0.48) C1RF7F3ELANEKLK7
SCHEMBL949951 0.77 C1R (0.44) C1RF7F3ELANEKLK7
SCHEMBL14542329 0.76 F7 (0.47) C1RF7F3ELANEKLK7
SCHEMBL12528482 0.75 C1R (0.41) C1RF7F3ELANEKLK7
SCHEMBL14698109 0.73 METAP2 (0.36) C1RF7F3ELANEKLK7
SCHEMBL31377057 0.72 CYP17A1 (0.39) F7F3ELANEAPEX1MAPT
SCHEMBL1697002 0.69 KLK7 (0.33) C1RF7F3ELANEKLK7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7968573-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-06-28 — — US disclosed
EP-1937664-B1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2011-06-15 — — EP disclosed
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME IKEGAMI HIROSHI 2011-03-24 — — US disclosed
US-7867949-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-11 — — US disclosed
EP-2251336-A1 Hydrazide compounds as intermediates of pesticides Sumitomo Chemical Company, Limited (JP) 2010-11-17 — — EP disclosed
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-16 — — US disclosed
WO-2007043677-A9 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2007-06-07 — — WO disclosed
WO-2007043677-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-04-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, H1-2, H1-0 C1R 1132/4885F7 2631/4885F3 1230/4885
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same ACHE, DDT, CAT C1R 4485/4885F7 3150/4885F3 3914/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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