SCHEMBL125285

SCHEMBL125285

Nc1ccnc2c(NCCO)cnn12

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NUDT1 P36639 1/20 0.37
SMN1; SMN2 Q16637 2/20 0.34
PKM P14618 1/20 0.34
KMT2A Q03164 1/20 0.34
TP53 P04637 2/20 0.34
MAPT P10636 2/20 0.34
CYP3A4 P08684 1/20 0.34
CASP1 P29466 1/20 0.34
BLM P54132 1/20 0.34
CASP7 P55210 1/20 0.34
IRAK4 Q9NWZ3 1/20 0.34
KCNQ3 O43525 1/20 0.33
KCNQ2 O43526 1/20 0.33
CDK1 P06493 1/20 0.33
HRH4 Q9H3N8 1/20 0.33
POLB P06746 2/20 0.32
KDM4E B2RXH2 2/20 0.32
ALDH1A1 P00352 1/20 0.32
GAA P10253 1/20 0.32
FLT3 P36888 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6159780 0.82 SMN1; SMN2 (0.34) NUDT1SMN1; SMN2PKMKMT2ATP53
SCHEMBL7559366 0.75 SMN1; SMN2 (0.40) SMN1; SMN2PKMKMT2ATP53MAPT
SCHEMBL1824267 0.74
SCHEMBL3840759 0.73 TYK2 (0.34) KCNQ3KCNQ2KDM4EMAP2K1CLK4
SCHEMBL126959 0.73 SMPD3 (0.35) NUDT1SMN1; SMN2KMT2ATP53MAPT
SCHEMBL5690529 0.73
SCHEMBL15069641 0.73 SMPD3 (0.30) KDM4EALDH1A1CLK4
SCHEMBL4748255 0.72 MAP2K1 (0.31) MAP2K1CLK4DYRK1B
SCHEMBL126958 0.71 LMNA (0.32) SMN1; SMN2TP53MAP2K1CLK4DYRK1B
SCHEMBL125976 0.70 SMPD3 (0.50) SMN1; SMN2KMT2ATP53MAPTCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2326 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1443890-B1 OXIDATION COLOURING AGENT BASED ON BICYCLIC DEVELOPER COMPONENTS HENKEL AG & CO KGAA (DE) 2010-01-13 EP claimed
EP-1319393-B1 Composition for dyeing keratin fibres with an alcohol oxidase and process for applying this composition OREAL (FR) 2009-09-02 EP claimed
EP-1413286-B1 Dyeing composition comprising at least one heterocyclic oxidation base and at least one substituted 2,3-diaminopyridine as a coupling agent OREAL (FR) 2009-04-22 EP claimed
EP-1352636-B1 Oxidation dyeing composition for keratin fibers comprising 2-chloro-6-methyl-3-aminophenol and an oxidation base, and dyeing method OREAL (FR) 2009-04-22 EP claimed
EP-1405627-B1 Antipenetrating hair pretreatment composition based on polyethelenoxide polymer(s) and process using said composition for limiting skin penetration by colourants OREAL (FR) 2008-04-30 EP claimed
US-7282067-B2 Composition for dyeing keratin fibres, containing an alcohol oxidase, and process using this composition L'OREAL (FR) 2007-10-16 US claimed
WO-2007071686-A1 COMPOSITION FOR DYEING KERATIN FIBRES WITH A TETRAAZAPENTAMETHINE CATIONIC DIRECT DYE, AN OXIDATION BASE AND A PARTICULAR COUPLER L'ORÉAL (FR) 2007-06-28 WO claimed
WO-2007071688-A1 COMPOSITION FOR DYEING KERATIN FIBRES WITH A TETRAAZAPENTAMETHINE CATIONIC DIRECT DYE, A PARTICULAR OXIDATION BASE AND A COUPLER L'ORÉAL (FR) 2007-06-28 WO claimed
US-7189267-B2 Oxyethylenated based hair pre-treatment anti-penetration composition and method using such a composition for limiting the penetration of dyes into the skin L'OREAL (FR) 2007-03-13 US claimed
US-7077871-B2 Coloring composition for keratin fibres comprising a system limiting the transcutaneous passage of an oxidation dye L'OREAL (FR) 2006-07-18 US claimed
EP-0966951-A1 Dye composition containing 1,8-bis-(2,5-diaminophenoxy)-3,5-dioxaoctane, an additional oxidation base and a coupler, and dyeing process L'OREAL (FR) 1999-12-29 EP claimed
EP-0966252-A1 OXIDATION DYEING COMPOSITION FOR KERATIN FIBRES COMPRISING 2-CHLORO 6 METHYL 3-AMINOPHENOL AND AN OXIDATION BASE, AND DYEING METHOD L'OREAL (FR) 1999-12-29 EP claimed
WO-1999066891-A1 OXIDATION DYEING COMPOSITION FOR KERATINOUS FIBRES AND DYEING METHOD USING SAME L'OREAL (FR) 1999-12-29 WO claimed
WO-1999066892-A1 OXIDATION DYEING COMPOSITION FOR KERATINOUS FIBRES AND DYEING METHOD USING SAME L'OREAL (FR) 1999-12-29 WO claimed
WO-1999048465-A1 OXIDATION DYEING COMPOSITION FOR KERATINOUS FIBRES CONTAINING A 3-AMINOPYRIDINE AZO DERIVATIVE AND DYEING METHOD USING SAID COMPOSITION L'OREAL (FR) 1999-09-30 WO claimed
WO-1999036039-A1 KERATINOUS FIBRE OXIDATION DYEING COMPOSITION CONTAINING A LACCASE AND DYEING METHOD USING SAME L'OREAL (FR) 1999-07-22 WO claimed
WO-1999011230-A1 OXIDATION DYEING COMPOSITION FOR KERATIN FIBRES COMPRISING 2-CHLORO 6 METHYL 3-AMINOPHENOL AND AN OXIDATION BASE, AND DYEING METHOD L'OREAL (FR) 1999-03-11 WO claimed
WO-1998055083-A1 KERATIN FIBRE OXIDATION DYEING COMPOSITION AND DYEING METHOD USING SAME L'OREAL (FR) 1998-12-10 WO claimed
EP-0847271-A1 PYRAZOLO-(1,5-a)-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND HAIR DYES CONTAINING THESE L'OREAL (FR) 1998-06-17 EP claimed
WO-1997049378-A1 PYRAZOLO-(1,5-a)-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND HAIR DYES CONTAINING THESE L'OREAL (FR) 1997-12-31 WO claimed