SCHEMBL12528645

SCHEMBL12528645

Cc1cc(Br)c2nc(-c3cc(Cl)c(Cl)n3-c3ncccc3Cl)oc(=O)c2c1

nearest known ligand 0.35

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 2/20 0.35
▸ C1R P00736 3/20 0.32
▸ KDM4E B2RXH2 3/20 0.32
▸ ALDH1A1 P00352 2/20 0.32
▸ POLB P06746 2/20 0.32
▸ MEN1 O00255 1/20 0.32
▸ KMT2A Q03164 1/20 0.32
▸ PTK2B Q14289 1/20 0.32
▸ RAB9A P51151 1/20 0.32
▸ TRPV1 Q8NER1 1/20 0.32
▸ NPSR1 Q6W5P4 1/20 0.32
▸ PBRM1 Q86U86 1/20 0.31
▸ DHODH Q02127 1/20 0.31
▸ HSD11B1 P28845 1/20 0.31
▸ PHGDH O43175 1/20 0.31
▸ SLC40A1 Q9NP59 1/20 0.30
▸ TNKS O95271 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12528853 0.95 MAPT (0.34) MAPTC1RKDM4EALDH1A1POLB
SCHEMBL12528626 0.90 SLC40A1 (0.35) MAPTC1RKDM4EALDH1A1MEN1
SCHEMBL950237 0.90 RAB9A (0.40) MAPTC1RKDM4EALDH1A1MEN1
SCHEMBL12528897 0.86 MAPT (0.32) MAPT
SCHEMBL950765 0.85 RAB9A (0.39) MAPTC1RKDM4EKMT2ARAB9A
SCHEMBL12528215 0.85 DHODH (0.35) MAPTKDM4EALDH1A1POLBMEN1
SCHEMBL12528603 0.85 TRPV1 (0.34) MAPTKDM4EALDH1A1POLBMEN1
SCHEMBL950558 0.85 DHODH (0.41) MAPTKDM4EALDH1A1POLBMEN1
SCHEMBL12528613 0.85 MAPT (0.34) MAPTC1RKDM4EALDH1A1POLB
SCHEMBL951593 0.84 NPSR1 (0.34) MAPTC1RALDH1A1POLBTRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7968573-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-06-28 — — US disclosed
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME IKEGAMI HIROSHI 2011-03-24 — — US disclosed
US-7867949-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-11 — — US disclosed
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, H1-2, H1-0 MAPT 4535/4885C1R 1132/4885KDM4E 1084/4885
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same ACHE, DDT, CAT MAPT 3656/4885C1R 4485/4885KDM4E 2028/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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