Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1169464 | 0.81 | PRMT1 (0.74) | SMN1; SMN2ALDH1A1LMNATSHR | |
| SCHEMBL20379469 | 0.79 | NPC1 (0.78) | SMN1; SMN2ALDH1A1ALOX15KMT2AMEN1 | |
| SCHEMBL21065524 | 0.77 | SMN1; SMN2 (0.79) | SMN1; SMN2ALDH1A1ALOX15KMT2AMEN1 | |
| SCHEMBL29460273 | 0.77 | SMN1; SMN2 (0.79) | SMN1; SMN2ALDH1A1ALOX15KMT2AMEN1 | |
| SCHEMBL175437 | 0.75 | NPC1 (0.72) | SMN1; SMN2ALOX15KMT2AMEN1MAPT | |
| SCHEMBL11626590 | 0.75 | POLB (0.74) | SMN1; SMN2ALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL1830014 | 0.75 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL1830012 | 0.75 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL19361072 | 0.73 | ALDH1A1 (0.77) | SMN1; SMN2ALDH1A1MAPTLMNACYP3A4 | |
| SCHEMBL10913233 | 0.72 | SMN1; SMN2 (0.66) | SMN1; SMN2ALDH1A1HPGDKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703749-B2 | Compositions and methods for treating Friedreich's Ataxia | FRATAGENE THERAPEUTICS S.R.L. (IT) | 2014-04-22 | — | — | US | disclosed |
| US-20130109658-A1 | COMPOSITIONS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA | FRATAGENE THERAPEUTICS S.R.L. (IT) | 2013-05-02 | — | — | US | disclosed |
| WO-2011070444-A2 | COMPOSITIONS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA | TESTI ROBERTO (IT) | 2011-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130109658-A1 | COMPOSITIONS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA | ATXN2, ATXN2L, ATXN10 | PTGS1 2687/4885PTGS2 2552/4885SMN1; SMN2 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.