Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ2 | O43526 | 4/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.31 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.31 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.31 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.31 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12307576 | 0.89 | ITGB3 (0.38) | KCNQ2CACNA1GCACNA1HCACNA1CCACNA1I | |
| SCHEMBL12307574 | 0.84 | RIPK1 (0.35) | KCNQ2DDB1CRBNMAPK14 | |
| SCHEMBL12307489 | 0.82 | KMT2A (0.39) | — | |
| SCHEMBL12307530 | 0.81 | MEN1 (0.34) | — | |
| SCHEMBL12334409 | 0.81 | SMN1; SMN2 (0.37) | MAPK14 | |
| SCHEMBL12307398 | 0.81 | GCK (0.40) | MAPK14 | |
| SCHEMBL12307524 | 0.80 | ALDH1A1 (0.42) | — | |
| SCHEMBL12307586 | 0.79 | KMT2A (0.40) | — | |
| SCHEMBL12307511 | 0.79 | ALDH1A1 (0.43) | — | |
| SCHEMBL12307484 | 0.79 | KMT2A (0.40) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2327704-A1 | RING-FUSED AZOLE DERIVATIVE HAVING PI3K-INHIBITING ACTIVITY | Shionogi&Co., Ltd. (JP) | 2011-06-01 | — | — | EP | disclosed |