Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.58 |
| ▸ | APP | P05067 | 3/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12542009 | 1.00 | HDAC8 (0.58) | HDAC8APPALOX5MAPTNPC1 | |
| SCHEMBL12541737 | 0.93 | ALOX5 (0.56) | HDAC8APPALOX5MAPTNPC1 | |
| SCHEMBL12541741 | 0.93 | ALOX5 (0.56) | HDAC8APPALOX5MAPTNPC1 | |
| SCHEMBL22754637 | 0.91 | HDAC8 (0.57) | HDAC8APPALOX5MAPTNPC1 | |
| SCHEMBL12695487 | 0.91 | HDAC8 (0.51) | HDAC8APPPDE4APDE4BPDE4C | |
| SCHEMBL7751091 | 0.85 | HDAC8 (0.62) | HDAC8APPMAPTNPC1RAB9A | |
| SCHEMBL7751094 | 0.85 | HDAC8 (0.62) | HDAC8APPMAPTNPC1RAB9A | |
| SCHEMBL12695565 | 0.85 | CHRNA7 (0.50) | HDAC8APPALOX5MAPTPTPN1 | |
| SCHEMBL22754654 | 0.84 | APP (0.57) | HDAC8APPALOX5MAPTNPC1 | |
| SCHEMBL8682788 | 0.84 | HDAC8 (0.75) | HDAC8APPMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3822246-A1 | COMPOUNDS AND METHODS FOR PREPARATION OF DIARYLPROPANES | Unigen, Inc. (US) | 2021-05-19 | — | — | EP | disclosed |
| EP-2688860-B1 | COMPOUNDS AND METHODS FOR PREPARATION OF DIARYLPROPANES | UNIGEN INC (US) | 2020-12-09 | — | — | EP | disclosed |
| US-20160096795-A1 | COMPOUNDS AND METHODS FOR PREPARATION OF DIARYLPROPANES | UNIGEN INC (US) | 2016-04-07 | — | — | US | disclosed |
| US-9045405-B2 | Compounds and methods for preparation of diarylpropanes | UNIGEN, INC. (US) | 2015-06-02 | — | — | US | disclosed |
| US-20140235899-A1 | COMPOUNDS AND METHODS FOR PREPARATION OF DIARYLPROPANES | UNIGEN, INC. (US) | 2014-08-21 | — | — | US | disclosed |
| EP-2688860-A1 | COMPOUNDS AND METHODS FOR PREPARATION OF DIARYLPROPANES | Unigen, Inc. (US) | 2014-01-29 | — | — | EP | disclosed |
| US-8586799-B2 | Compounds and methods for preparation of diarylpropanes | UNIGEN, INC. (US) | 2013-11-19 | — | — | US | disclosed |
| US-20120245393-A1 | COMPOUNDS AND METHODS FOR PREPARATION OF DIARYLPROPANES | UNIGEN, INC. (US) | 2012-09-27 | — | — | US | disclosed |
| WO-2012129260-A1 | COMPOUNDS AND METHODS FOR PREPARATION OF DIARYLPROPANES | UNIGEN, INC. (US) | 2012-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160096795-A1 | COMPOUNDS AND METHODS FOR PREPARATION OF DIARYLPROPANES | DDT, QDPR, NPY1R | HDAC8 1660/4885APP 195/4885ALOX5 1646/4885 |
| US-20120245393-A1 | COMPOUNDS AND METHODS FOR PREPARATION OF DIARYLPROPANES | DDT, QDPR, NPY1R | HDAC8 1660/4885APP 195/4885ALOX5 1646/4885 |
| US-20140235899-A1 | COMPOUNDS AND METHODS FOR PREPARATION OF DIARYLPROPANES | DDT, QDPR, NPY1R | HDAC8 1660/4885APP 195/4885ALOX5 1646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.