Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Betahistine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.96 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | APP | P05067 | 3/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Betahistine SCHEMBL60646 | 1.00 | LMNA (1.00) | LMNAALDH1A1TAAR1ALOX15HRH3 | |
| Betahistine SCHEMBL5373612 | 0.98 | LMNA (0.96) | LMNAALDH1A1TAAR1ALOX15HRH3 | |
| Betahistine SCHEMBL28346535 | 0.98 | HRH3 (1.00) | LMNAALDH1A1TAAR1ALOX15HRH3 | |
| Betahistine SCHEMBL29354603 | 0.98 | HRH3 (1.00) | LMNAALDH1A1TAAR1ALOX15HRH3 | |
| Betahistine SCHEMBL125582 | 0.98 | HRH3 (1.00) | LMNAALDH1A1TAAR1ALOX15HRH3 | |
| Betahistine SCHEMBL11315542 | 0.96 | HRH3 (0.96) | LMNAALDH1A1TAAR1ALOX15HRH3 | |
| Betahistine SCHEMBL20421886 | 0.96 | HRH3 (0.96) | LMNAALDH1A1TAAR1ALOX15HRH3 | |
| Betahistine SCHEMBL20639365 | 0.96 | HRH3 (0.96) | LMNAALDH1A1TAAR1ALOX15HRH3 | |
| Betahistine SCHEMBL20421889 | 0.96 | HRH3 (0.96) | LMNAALDH1A1TAAR1ALOX15HRH3 | |
| Betahistine SCHEMBL1649204 | 0.96 | HRH3 (0.96) | LMNAALDH1A1TAAR1ALOX15HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 393 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120189391-A | Betahistine hydrochloride tablet and preparation method thereof | 珠海润都制药股份有限公司 | 2025-06-24 | — | — | CN | claimed |
| CN-115350192-B | Pharmaceutical compositions comprising inhibitors of Akt protein kinase | 豪夫迈·罗氏有限公司 | 2025-05-13 | — | — | CN | claimed |
| CN-119386014-A | Betahistine oral solid preparation for improving stability and preparation method thereof | 卡文迪许(泰州)药业有限公司 | 2025-02-07 | — | — | CN | claimed |
| CN-222104113-U | Betahistine hydrochloride tablet drying device | 重庆科瑞制药(集团)有限公司 | 2024-12-03 | — | — | CN | claimed |
| CN-118662455-A | Preparation method of betahistine hydrochloride medicament | 乐普恒久远药业有限公司 | 2024-09-20 | — | — | CN | claimed |
| CN-118436591-A | External preparation of betahistine and application thereof | 山东序列生物科技有限公司 | 2024-08-06 | — | — | CN | claimed |
| CN-118356397-A | Intranasal compositions comprising betahistine | 欧托拉农股份有限公司 | 2024-07-19 | — | — | CN | claimed |
| CN-221259428-U | Betahistine hydrochloride bulk drug dryer structure | 焦作市民康药业有限公司 | 2024-07-02 | — | — | CN | claimed |
| CN-220938636-U | Instrument disinfection device for preparing betahistine hydrochloride injection | 焦作市民康药业有限公司 | 2024-05-14 | — | — | CN | claimed |
| CN-117476120-B | Synthesis method of betahistine hydrochloride, normalization evaluation method and device of synthesis parameters | 黑龙江中桂制药有限公司 | 2024-05-03 | — | — | CN | claimed |
| CN-101987081-A | Controlled release preparation | SHUGUANG ZHONG | 2011-03-23 | — | — | CN | claimed |
| CN-101987083-A | Preparation method for controlled release preparation, especial for zero-order release controlled release preparation | SHUGUANG ZHONG | 2011-03-23 | — | — | CN | claimed |
| CN-101919803-A | A kind of controlled release preparation | SHUGUANG ZHONG | 2010-12-22 | — | — | CN | claimed |
| US-7803559-B1 | Protein aggregation regulators | THE REGENTS OF THE UNIVERSITY OF CA (US) | 2010-09-28 | — | — | US | claimed |
| US-20090298892-A1 | Treatment Methods Employing Histamine H3 Receptor Antagonists, Including Betahistine | OTOLANUM AG, C/O AURIS MEDICAL HOLDING AG (CH) | 2009-12-03 | — | — | US | claimed |
| CN-101288659-A | Floating type pellets in stomach and preparation method thereof | LEIBO WANG (CN) | 2008-10-22 | — | — | CN | claimed |
| WO-2007076140-A2 | TREATMENT METHODS EMPLOYING HISTAMINE H3 RECEPTOR ANTAGONISTS, INCLUDING BETAHISTINE | UNIVERSITY OF CINCINNATI (US) | 2007-07-05 | — | — | WO | claimed |
| CN-1732934-A | Freeze dry betahistine hydrochloride injection and method for preparing the same | CHEN XUEFENG (CN) | 2006-02-15 | — | — | CN | claimed |
| CN-1568986-A | Dripping pills of betahistine hydrochloride and its preparation method | NANCHANG HELIOEAST SCIENCE & TECHNOLOGY CO LTD (CN) | 2005-01-26 | — | — | CN | claimed |
| US-4159332-A | Prevention of or reduction in severity of myocardial infarction | UNIMED, INC. (US) | 1979-06-26 | — | — | US | claimed |