Betahistine

Betahistine

SCHEMBL60646

CNCCc1ccccn1.Cl.Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

HRH1HRH3

The experimentally established mechanism targets of Betahistine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HRH3 known ✓ Q9Y5N1 1/20 0.96
HRH1 known ✓ P35367 1/20 0.53
LMNA P02545 2/20 1.00
ALDH1A1 P00352 2/20 1.00
TAAR1 Q96RJ0 1/20 1.00
ALOX15 P16050 1/20 1.00
TDP1 Q9NUW8 1/20 0.77
CYP1A2 P05177 3/20 0.59
CYP2C19 P33261 1/20 0.59
NPC1 O15118 1/20 0.55
RAB9A P51151 1/20 0.55
APP P05067 3/20 0.54
CYP2D6 P10635 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Betahistine SCHEMBL654358 1.00 LMNA (1.00) LMNAALDH1A1TAAR1ALOX15HRH3
Betahistine SCHEMBL5373612 0.98 LMNA (0.96) LMNAALDH1A1TAAR1ALOX15HRH3
Betahistine SCHEMBL28346535 0.98 HRH3 (1.00) LMNAALDH1A1TAAR1ALOX15HRH3
Betahistine SCHEMBL29354603 0.98 HRH3 (1.00) LMNAALDH1A1TAAR1ALOX15HRH3
Betahistine SCHEMBL125582 0.98 HRH3 (1.00) LMNAALDH1A1TAAR1ALOX15HRH3
Betahistine SCHEMBL11315542 0.96 HRH3 (0.96) LMNAALDH1A1TAAR1ALOX15HRH3
Betahistine SCHEMBL20421886 0.96 HRH3 (0.96) LMNAALDH1A1TAAR1ALOX15HRH3
Betahistine SCHEMBL20639365 0.96 HRH3 (0.96) LMNAALDH1A1TAAR1ALOX15HRH3
Betahistine SCHEMBL20421889 0.96 HRH3 (0.96) LMNAALDH1A1TAAR1ALOX15HRH3
Betahistine SCHEMBL1649204 0.96 HRH3 (0.96) LMNAALDH1A1TAAR1ALOX15HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3352 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4724917-A1 END-TO-END CONTEXT ISOLATION ACROSS MICROSERVICES IN A MULTI-TENANT DISTRIBUTED CLOUD INFRASTRUCTURE Microsoft Technology Licensing, LLC (US) 2026-04-15 EP claimed
US-20260044393-A1 SYSTEMS AND METHODS FOR COLLECTING AND DISTRIBUTING DIGITAL INFORMATION THE PNC FINANCIAL SERVICES GROUP, INC. (US) 2026-02-12 US claimed
EP-4673146-A2 METHODS FOR TREATING OBSESSIVE COMPULSIVE RELATED DISORDERS, TIC DISORDERS AND GLUTAMATE EXCITOTOXICITY RELATED DISORDERS Biohaven Therapeutics Ltd. (VG) 2026-01-07 EP claimed
EP-3621593-B1 PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING CARDIOVASCULAR DISEASES SPACEMED X LLC (US) 2025-07-09 EP claimed
CN-120189391-A Betahistine hydrochloride tablet and preparation method thereof 珠海润都制药股份有限公司 2025-06-24 CN claimed
CN-119850241-A Electricity sales quantity prediction method and system based on power user group clustering 国网辽宁省电力有限公司经济技术研究院 2025-04-18 CN claimed
US-20250068251-A1 Method For a Gesture Recognition System for Improving Gesture Recognition, Device, Computer Program and Vehicle BAYERISCHE MOTOREN WERKE AKTIENGESELLSCHAFT (DE) 2025-02-27 US claimed
CN-119386014-A Betahistine oral solid preparation for improving stability and preparation method thereof 卡文迪许(泰州)药业有限公司 2025-02-07 CN claimed
WO-2024258598-A1 END-TO-END CONTEXT ISOLATION ACROSS MICROSERVICES IN A MULTI-TENANT DISTRIBUTED CLOUD INFRASTRUCTURE MICROSOFT TECHNOLOGY LICENSING, LLC (US) 2024-12-19 WO claimed
CN-222104113-U Betahistine hydrochloride tablet drying device 重庆科瑞制药(集团)有限公司 2024-12-03 CN claimed
EP-0743573-B1 Method for obtaining image contrast migration imaging members XEROX CORP (US) 2000-09-06 EP claimed
WO-1999026966-A2 NUCLEAR RECEPTOR LIGANDS AND LIGAND BINDING DOMAINS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1999-06-03 WO claimed
EP-0743573-A2 Method for obtaining image contrast migration imaging members XEROX CORPORATION (US) 1996-11-20 EP claimed
EP-0743574-A2 Migration imaging members XEROX CORPORATION (US) 1996-11-20 EP claimed
US-5563014-A SOFTENABLE LAYER CONTAINIG PHOTOSENSITIVE MARKING MATERIAL; TRANSPARENTIZING AGENT XEROX CORPORATION (US) 1996-10-08 US claimed
US-5514505-A SELECTIVE TRANSPARENTIZATION OF PHOTOSENSITIVE MIGRATION MARKING PARTICLES EMBEDDED NEAR THE SURFACE OF A SOFTENABLE LAYER SUPPORTED BY AN ELECTROCONDUCTIVE SUBSTRATE XEROX CORPORATION (US) 1996-05-07 US claimed
EP-0232262-A4 TRYPTOPHAN PRODUCING MICROORGANISM. STAUFFER CHEMICAL CO (US) 1989-09-19 EP claimed
EP-0232262-A1 TRYPTOPHAN PRODUCING MICROORGANISM STAUFFER CHEMICAL COMPANY (US) 1987-08-19 EP claimed
WO-1987001130-A1 TRYPTOPHAN PRODUCING MICROORGANISM STAUFFER CHEMICAL COMPANY (US) 1987-02-26 WO claimed
US-4159332-A Prevention of or reduction in severity of myocardial infarction UNIMED, INC. (US) 1979-06-26 US claimed