Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.62 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.55 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.51 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12349143 | 0.81 | PIK3CD (0.56) | CYP3A4PIK3CDMAP4K4CYP1A2KCNH2 | |
| SCHEMBL12492898 | 0.81 | CYP3A4 (0.59) | CYP3A4TSHRALDH1A1MAPK1PIK3CD | |
| SCHEMBL29365311 | 0.81 | CYP3A4 (0.94) | CYP3A4TSHRALDH1A1MAPK1ESR2 | |
| SCHEMBL8872306 | 0.81 | CYP3A4 (0.94) | CYP3A4TSHRALDH1A1MAPK1ESR2 | |
| SCHEMBL49382 | 0.81 | CYP3A4 (0.94) | CYP3A4TSHRALDH1A1MAPK1ESR2 | |
| SCHEMBL23137319 | 0.79 | CYP3A4 (0.90) | CYP3A4TSHRALDH1A1MAPK1ESR2 | |
| Hydrochloric Acid SCHEMBL29368557 | 0.79 | CYP3A4 (1.00) | CYP3A4TSHRALDH1A1MAPK1ESR2 | |
| Hydrochloric Acid SCHEMBL30242948 | 0.79 | CYP3A4 (1.00) | CYP3A4TSHRALDH1A1MAPK1ESR2 | |
| Hydrochloric Acid SCHEMBL864592 | 0.79 | CYP3A4 (1.00) | CYP3A4TSHRALDH1A1MAPK1ESR2 | |
| Hydrochloric Acid SCHEMBL2571374 | 0.79 | CYP3A4 (1.00) | CYP3A4TSHRALDH1A1MAPK1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130035326-A1 | BIARYL COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2013-02-07 | — | — | US | disclosed |
| EP-2467137-A1 | BIARYL COMPOUNDS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2012-06-27 | — | — | EP | disclosed |
| WO-2011022473-A1 | BIARYL COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2011-02-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130035326-A1 | BIARYL COMPOUNDS AND METHODS OF USE THEREOF | FLT3, CSF3R, CSF1R | CYP3A4 2332/4885TSHR 2007/4885ALDH1A1 1695/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.