Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.71 |
| ▸ | GAA known ✓ | P10253 | 2/20 | 0.50 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.46 |
| ▸ | CACNA1B known ✓ | Q00975 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 8/20 | 1.00 |
| ▸ | TSHR | P16473 | 8/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | AHR | P35869 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30242948 | 1.00 | CYP3A4 (1.00) | CYP3A4TSHRALDH1A1MAPK1ESR2 | |
| Hydrochloric Acid SCHEMBL864592 | 1.00 | CYP3A4 (1.00) | CYP3A4TSHRALDH1A1MAPK1ESR2 | |
| Hydrochloric Acid SCHEMBL29368557 | 1.00 | CYP3A4 (1.00) | CYP3A4TSHRALDH1A1MAPK1ESR2 | |
| SCHEMBL8872306 | 0.97 | CYP3A4 (0.94) | CYP3A4TSHRALDH1A1MAPK1ESR2 | |
| SCHEMBL49382 | 0.97 | CYP3A4 (0.94) | CYP3A4TSHRALDH1A1MAPK1ESR2 | |
| SCHEMBL29365311 | 0.97 | CYP3A4 (0.94) | CYP3A4TSHRALDH1A1MAPK1ESR2 | |
| SCHEMBL23137319 | 0.94 | CYP3A4 (0.90) | CYP3A4TSHRALDH1A1MAPK1ESR2 | |
| Methane SCHEMBL27949876 | 0.94 | CYP3A4 (0.90) | CYP3A4TSHRALDH1A1MAPK1ESR2 | |
| Nitrogen SCHEMBL28358917 | 0.92 | CYP3A4 (0.85) | CYP3A4TSHRALDH1A1MAPK1ESR2 | |
| Benzidine SCHEMBL1660896 | 0.91 | CYP3A4 (0.82) | CYP3A4TSHRALDH1A1MAPK1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 114 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117756640-A | Method for preparing high-purity 3,3' -diaminobenzidine by two-step heating method | 江苏宝众宝达药业股份有限公司 | 2024-03-26 | — | — | CN | claimed |
| CN-117342954-A | Continuous production process of 3,3' -dichlorobenzidine hydrochloride | 辽宁兰得新材料科技发展有限公司 | 2024-01-05 | — | — | CN | claimed |
| CN-117282354-A | Loading attachment is used in preparation of 3,3' -dichloro biphenyl amine hydrochloride | 辽宁兰得新材料科技发展有限公司 | 2023-12-26 | — | — | CN | claimed |
| CN-218529988-U | 3,3' -dichlorobenzidine hydrochloride centrifugal material recovery device | 辽宁兰得新材料科技发展有限公司 | 2023-02-28 | — | — | CN | claimed |
| CN-218046723-U | Automatic layering tank for 3,3' -dichlorobenzidine hydrochloride material | 辽宁兰得新材料科技发展有限公司 | 2022-12-16 | — | — | CN | claimed |
| CN-217490786-U | 3, 3' -dichlorobenzidine hydrochloride preparation is with loading attachment | 辽宁兰得新材料科技发展有限公司 | 2022-09-27 | — | — | CN | claimed |
| CN-110627653-B | Method for synthesizing 3, 3' -dichlorobenzidine hydrochloride by hydrochloric acid transposition | 中国石油化工股份有限公司 | 2022-04-15 | — | — | CN | claimed |
| CN-113717546-A | Method for preparing organic pigment yellow and pigment orange by modifying attapulgite | 宇虹颜料股份有限公司 | 2021-11-30 | — | — | CN | claimed |
| CN-113548972-A | Production process of 3, 3' -dichlorobenzidine hydrochloride | 济宁祥泰和新材料科技有限公司 | 2021-10-26 | — | — | CN | claimed |
| CN-109651836-B | Industrial production method of low PCBs environment-friendly yellow pigment PY83 for plastic | 浙江科隆颜料科技有限公司 | 2020-12-01 | — | — | CN | claimed |
| CN-107540077-B | Catalytic oxidation treatment method for neutralizing wastewater by 3, 3' -dichlorobenzidine hydrochloride | 中国石油化工股份有限公司 | 2020-08-21 | — | — | CN | claimed |
| CN-210646302-U | Feeding device is used in preparation of 3,3' -dichlorobenzidine hydrochloride | 山东隆盛和助剂有限公司 | 2020-06-02 | — | — | CN | claimed |
| CN-110627653-A | Method for synthesizing 3, 3' -dichlorobenzidine hydrochloride by hydrochloric acid transposition | 中国石油化工股份有限公司 | 2019-12-31 | — | — | CN | claimed |
| CN-108559298-B | Application of multi-block copolymer containing PPO-PEO and PDMS in preparation of modified organic pigment | 百合花集团股份有限公司 | 2019-12-06 | — | — | CN | claimed |
| CN-117756640-A | Method for preparing high-purity 3,3' -diaminobenzidine by two-step heating method | 江苏宝众宝达药业股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-117756640-A | Method for preparing high-purity 3,3' -diaminobenzidine by two-step heating method | 江苏宝众宝达药业股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-117342954-A | Continuous production process of 3,3' -dichlorobenzidine hydrochloride | 辽宁兰得新材料科技发展有限公司 | 2024-01-05 | — | — | CN | disclosed |
| US-5034063-A | Pigments for printing | TOYO INK MANUFACTURING CO., LTD. (JP) | 1991-07-23 | — | — | US | disclosed |
| EP-0365346-A2 | Diazo pigment composition | TOYO INK MANUFACTURING CO., LTD. (JP) | 1990-04-25 | — | — | EP | disclosed |
| US-4295889-A | STORAGE STABILITY | CANON KABUSHIKI KAISHA (JP) | 1981-10-20 | — | — | US | disclosed |