Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 6/20 | 0.40 |
| ▸ | KLK1 | P06870 | 6/20 | 0.40 |
| ▸ | NAE1 | Q13564 | 3/20 | 0.40 |
| ▸ | UBA3 | Q8TBC4 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GRK5 | P34947 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | UBA6 | A0AVT1 | 1/20 | 0.33 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.33 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.33 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1795226 | 0.83 | NAE1 (0.47) | NAE1UBA3CA2 | |
| SCHEMBL12566825 | 0.81 | CA2 (0.34) | NAE1UBA3CA2GRK5CSNK1A1 | |
| SCHEMBL1798615 | 0.79 | NAE1 (0.40) | KLKB1KLK1NAE1UBA3CA2 | |
| SCHEMBL12566819 | 0.79 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17889881 | 0.77 | NAE1 (0.39) | KLKB1KLK1NAE1UBA3CA2 | |
| SCHEMBL13773407 | 0.74 | CA2 (0.43) | CA2ALDH1A1LMNACYP1A2 | |
| SCHEMBL12652426 | 0.74 | ATG7 (0.46) | NAE1UBA3CA2GRK5CSNK1A1 | |
| SCHEMBL12652607 | 0.70 | NR2F2 (0.54) | NPC1RAB9ASMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL12567124 | 0.70 | ABL1 (0.49) | CTSLNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL14430991 | 0.70 | ATG7 (0.53) | NAE1UBA3CA2GRK5CSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110136834-A1 | INHIBITORS OF E1 ACTIVATING ENZYMES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-06-09 | — | — | US | disclosed |
| US-7951810-B2 | Substituted pyrrolo[2,3-d]pyrimidines as inhibitors of E1 activating enzymes | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110136834-A1 | INHIBITORS OF E1 ACTIVATING ENZYMES | ECE1, RNASE1, RCE1 | KLKB1 1669/4885KLK1 1264/4885NAE1 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.