SCHEMBL1258591

SCHEMBL1258591

BrCc1nc2ccccc2nc1CBr

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.53
ERBB2 P04626 1/20 0.46
ALDH1A1 P00352 4/20 0.43
HPGD P15428 2/20 0.43
KDM4E B2RXH2 2/20 0.43
GAA P10253 1/20 0.43
HSD17B10 Q99714 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
NQO2 P16083 3/20 0.42
KMT2A Q03164 2/20 0.41
ELANE P08246 1/20 0.39
PDE10A Q9Y233 1/20 0.39
TRPA1 O75762 1/20 0.39
TSHR P16473 1/20 0.39
MEN1 O00255 1/20 0.39
NPC1 O15118 1/20 0.39
USP2 O75604 1/20 0.39
POLB P06746 1/20 0.39
CACNA1B Q00975 1/20 0.39
APBA1 Q02410 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30384601 1.00 MAPT (0.53) MAPTERBB2ALDH1A1HPGDKDM4E
SCHEMBL19470934 0.91 NQO2 (0.52) MAPTERBB2ALDH1A1HPGDKDM4E
SCHEMBL19937123 0.89 MAPT (0.42) MAPTERBB2ALDH1A1HPGDKDM4E
SCHEMBL31193178 0.85 MAPT (0.43) MAPTERBB2ALDH1A1HPGDKDM4E
SCHEMBL681846 0.84 TDP1 (0.58) MAPTERBB2ALDH1A1HPGDKDM4E
SCHEMBL681084 0.84 MAPT (0.42) MAPTERBB2ALDH1A1HPGDKDM4E
SCHEMBL7691783 0.82 NQO2 (0.54) MAPTERBB2ALDH1A1HPGDKDM4E
SCHEMBL1879471 0.80 ERBB2 (0.72) ERBB2ALDH1A1KDM4EGAAHSD17B10
SCHEMBL10562956 0.79 MAPT (0.48) MAPTERBB2ALDH1A1HPGDKDM4E
SCHEMBL15522442 0.79 KMT2A (0.64) MAPTERBB2ALDH1A1HPGDKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 91 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108358997-A A kind of stabilization polypeptide that intracellular that modifying construction of strategy using double sulfosalts is reversible 北京大学深圳研究生院 2018-08-03 CN claimed
CN-102584869-B 2-nuclear magnetic resonance imaging contrast agent taking 2, 3-biquinoxaline as connecting body and preparation method thereof CHANGCHUN APPLIED CHEMISTRY 2014-01-08 CN claimed
US-5939568-A Accelerated catalysis of olefinic epoxidations THE SCRIPPS RESEARCH INSTITUTE (US) 1999-08-17 US claimed
WO-1998033786-A9 ACCELERATED CATALYSIS OF OLEFINIC EPOXIDATIONS 1998-12-30 WO claimed
WO-1998033786-A1 ACCELERATED CATALYSIS OF OLEFINIC EPOXIDATIONS THE SCRIPPS RESEARCH INSTITUTE (US) 1998-08-06 WO claimed
EP-4687997-A2 ANTIBODY-DRUG CONJUGATES AND USES THEREOF Sorrento Therapeutics, Inc. (US) 2026-02-11 EP disclosed
US-20250205350-A1 Antibody-Drug Conjugates and Uses Thereof VIVASOR, INC. (US) 2025-06-26 US disclosed
US-20250092020-A1 IDO/TDO Inhibitor GENERAL INCORPORATED ASSOCIATION PHARMA VALLEY PROJECT SUPPORTING ORGANIZATION (JP) 2025-03-20 US disclosed
WO-2025031383-A1 BIFUNCTIONAL LINKER COMPOUND, ANTIBODY DRUG CONJUGATE, PREPARATION METHOD FOR ANTIBODY DRUG CONJUGATE, AND USE OF ANTIBODY DRUG CONJUGATE 杭州爱科瑞思生物医药有限公司 2025-02-13 WO disclosed
WO-2025021868-A1 TRAF2 INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER DISEASES Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) 2025-01-30 WO disclosed
US-12209079-B2 IDO/TDO inhibitor GENERAL INCORPORATED ASSOCIATION PHARMA VALLEY PROJECT SUPPORTING ORGANIZATION (JP) 2025-01-28 US disclosed
EP-4470560-A1 TUMOR IMMUNOTHERAPY Pingshan Translational Medicine Center, Shenzhen Bay Laboratory (CN) 2024-12-04 EP disclosed
US-5360797-A Bisphosphonic acid derivatives useful as anti-arthritic agents THE UPJOHN COMPANY (US) 1994-11-01 US disclosed
US-5298498-A Antiarthritic agents THE UPJOHN COMPANY (US) 1994-03-29 US disclosed
EP-0561948-A1 PHOSPHONIC ACID DERIVATIVES USEFUL AS ANTIINFLAMMATORY AGENTS. UPJOHN CO (US) 1993-09-29 EP disclosed
WO-1992014740-A1 QUINOXALINE PHOSPHONO-AMINO ACIDS AMERICAN HOME PRODUCTS CORPORATION (US) 1992-09-03 WO disclosed
WO-1992010504-A2 PHOSPHONIC ACID DERIVATIVES USEFUL AS ANTIINFLAMMATORY AGENTS THE UPJOHN COMPANY (US) 1992-06-25 WO disclosed
US-5118675-A Therapy for central nervous system disorders AMERICAN HOME PRODUCTS CORPORATION (US) 1992-06-02 US disclosed
EP-0389236-A2 Photopolymerisable composition Horsell Plc (GB) 1990-09-26 EP disclosed
US-3959100-A OPACIFIER SCM CORPORATION (US) 1976-05-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12209079-B2 IDO/TDO inhibitor IDO1, IDO2, TDO2 MAPT 609/4885ERBB2 1198/4885ALDH1A1 3331/4885
US-20250205350-A1 Antibody-Drug Conjugates and Uses Thereof ADCY6, ADCY10, ADCY7 MAPT 2402/4885ERBB2 560/4885ALDH1A1 591/4885
US-20250092020-A1 IDO/TDO Inhibitor IDO1, IDO2, TDO2 MAPT 609/4885ERBB2 1198/4885ALDH1A1 3331/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.