Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acetylcholine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 8/20 | 0.76 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.76 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.76 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.76 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.76 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.76 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.76 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.76 |
| ▸ | HTR1A | P08908 | 2/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.76 |
| ▸ | PGR | P06401 | 1/20 | 0.76 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.76 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.76 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.76 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.76 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.76 |
| ▸ | GALR3 | O60755 | 2/20 | 0.73 |
| ▸ | GAA | P10253 | 1/20 | 0.73 |
| ▸ | RAB9A | P51151 | 1/20 | 0.73 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetylcholine SCHEMBL27970924 | 0.94 | CHRM1 (0.79) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL27531690 | 0.92 | CHRM1 (0.83) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL1258635 | 0.90 | CHRM5 (0.73) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL28462553 | 0.90 | CHRM1 (0.79) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL29113198 | 0.87 | CHRM1 (0.91) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL2518957 | 0.87 | CHRM1 (1.00) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL3216 | 0.87 | CHRM1 (1.00) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL1899186 | 0.85 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL6023859 | 0.85 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL8513991 | 0.85 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110040248-A1 | METHODS AND IMPLANTABLE DEVICES FOR TREATING SUPRAVENTRICULAR ARRHYTHMIAS | CLOSED LOOP THERAPIES BV (NL) | 2011-02-17 | — | — | US | disclosed |
| US-7781402-B2 | Methods and implantable devices for treating supraventricular arrhythmias | CLOSED LOOP THERAPIES LTD. (IL) | 2010-08-24 | — | — | US | disclosed |
| EP-1809374-A4 | METHODS AND IMPLANTABLE DEVICES FOR TREATING SUPRAVENTRICULAR ARRHYTHMIAS | CLOSED LOOP THERAPIES LTD (IL) | 2008-09-10 | — | — | EP | disclosed |
| EP-1809374-A1 | METHODS AND IMPLANTABLE DEVICES FOR TREATING SUPRAVENTRICULAR ARRHYTHMIAS | Closed Loop Therapies Ltd. (IL) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006040765-A1 | METHODS AND IMPLANTABLE DEVICES FOR TREATING SUPRAVENTRICULAR ARRHYTHMIAS | CLOSED LOOP THERAPIES LTD. (IL) | 2006-04-20 | — | — | WO | disclosed |
| US-20060079941-A1 | Methods and implantable devices for treating supraventricular arrhythmias | CLOSED LOOP THERAPIES LTD. (IL) | 2006-04-13 | — | — | US | disclosed |