Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acetylcholine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 8/20 | 0.95 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.95 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.95 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.95 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.95 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.95 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.95 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.95 |
| ▸ | HTR1A | P08908 | 2/20 | 0.95 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.95 |
| ▸ | PGR | P06401 | 1/20 | 0.95 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.95 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.95 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.95 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.95 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.95 |
| ▸ | GALR3 | O60755 | 2/20 | 0.91 |
| ▸ | GAA | P10253 | 1/20 | 0.91 |
| ▸ | RAB9A | P51151 | 1/20 | 0.91 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetylcholine SCHEMBL2518957 | 0.97 | CHRM1 (1.00) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL3216 | 0.97 | CHRM1 (1.00) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL15687718 | 0.95 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL21925712 | 0.95 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL18227923 | 0.95 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL1899186 | 0.95 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL6023859 | 0.95 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL3904052 | 0.95 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL40885 | 0.95 | CHRM5 (1.00) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL1157050 | 0.95 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120136416-A1 | Caged Neuropeptides: modulation and measurement of synapse and signaling activity; and methods for drug evaluation, pharmaceuticals preparation and treatment | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-05-31 | — | — | US | disclosed |
| CN-101219191-B | Medicine for preventing and treating forestomach atony of ruminant | UNIV HEBEI AGRICULTURE | 2010-08-25 | — | — | CN | disclosed |
| CN-101219191-A | Medicine for preventing and treating forestomach atony of ruminant | UNIV HEBEI AGRICULTURE (CN) | 2008-07-16 | — | — | CN | disclosed |
| CN-1925877-A | Methylamine risk and treatment of hyperexcitability, depression and alcoholism with N-derivatives | TAPIO HILAKIVI ILKKA (FI) | 2007-03-07 | — | — | CN | disclosed |