Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | TACR2 | P21452 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272285 | 1.00 | FDPS (0.55) | FDPSMAPTSMN1; SMN2NPSR1LMNA | |
| SCHEMBL1259270 | 1.00 | FDPS (0.55) | FDPSMAPTSMN1; SMN2NPSR1LMNA | |
| SCHEMBL1259569 | 0.97 | FDPS (0.52) | FDPSMAPTSMN1; SMN2NPSR1LMNA | |
| SCHEMBL3276646 | 0.93 | FDPS (0.67) | FDPSMAPTSMN1; SMN2NPSR1LMNA | |
| SCHEMBL10497561 | 0.93 | FDPS (0.63) | FDPSMAPTSMN1; SMN2NPSR1LMNA | |
| SCHEMBL2945520 | 0.93 | FDPS (0.63) | FDPSMAPTSMN1; SMN2NPSR1LMNA | |
| SCHEMBL2948173 | 0.93 | FDPS (0.63) | FDPSMAPTSMN1; SMN2NPSR1LMNA | |
| SCHEMBL5053914 | 0.93 | FDPS (0.63) | FDPSMAPTSMN1; SMN2NPSR1LMNA | |
| SCHEMBL10497454 | 0.93 | FDPS (0.63) | FDPSMAPTSMN1; SMN2NPSR1LMNA | |
| SCHEMBL10497979 | 0.93 | FDPS (0.63) | FDPSMAPTSMN1; SMN2NPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110092739-A1 | Lipid Nanoparticle Based Compositions and Methods for the Delivery of Biologically Active Molecules | SIMA THERAPEUTICS, INC. (US) | 2011-04-21 | — | — | US | disclosed |
| US-7910363-B1 | Lipophilic polyamines providing enhanced intracellular delivery of agents by a polyamine transport system | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2011-03-22 | — | — | US | disclosed |
| US-7893302-B2 | novel cationic lipids based on 4-(aminomethyl)-1,2-bis-(fatty ether or ester)-benzene | SIRNA THERAPEUTICS, INC. (US) | 2011-02-22 | — | — | US | disclosed |
| US-20100105933-A1 | LIPID NANOPARTICLE BASED COMPOSITIONS AND METHODS FOR THE DELIVERY OF BIOLOGICALLY ACTIVE MOLECULES | CHEN TONGQIAN | 2010-04-29 | — | — | US | disclosed |
| US-7691405-B2 | Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules | SIRNA THERAPEUTICS, INC (US) | 2010-04-06 | — | — | US | disclosed |
| US-20100063308-A1 | LIPID NANOPARTICLE BASED COMPOSITIONS AND METHODS FOR THE DELIVERY OF BIOLOGICALLY ACTIVE MOLECULES | BANK OF AMERICA, N.A. | 2010-03-11 | — | — | US | disclosed |
| US-20100048888-A1 | Lipid Nanoparticle Based Compositions and Methods for the Delivery of Biologically Active Molecules | SIRNA THERAPEUTICS, INC., A WHOLLY OWNED SUBSIDIARY OF MERCK & CO., INC. | 2010-02-25 | — | — | US | disclosed |
| US-20100015218-A1 | COMPOSITIONS AND METHODS FOR POTENTIATED ACTIVITY OF BIOLOGICALLY ACTIVE MOLECULES | MERCK SHARP & DOHME CORP. | 2010-01-21 | — | — | US | disclosed |
| US-7641915-B2 | Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules | SIRNA THERAPEUTICS, INC (US) | 2010-01-05 | — | — | US | disclosed |
| EP-2131848-A2 | COMPOSITIONS AND METHODS FOR POTENTIATED ACTIVITY OF BIOLOGICALY ACTIVE MOLECULES | Merck & Co., Inc. (US) | 2009-12-16 | — | — | EP | disclosed |
| US-20090048197-A1 | Lipid Nanoparticle Based Compositions and Methods for the Delivery of Biologically Active Molecules | SIRNA THERAPEUTICS, INC. (US) | 2009-02-19 | — | — | US | disclosed |
| WO-2008147438-A2 | LIPID NANOPARTICLE BASED COMPOSITIONS AND METHODS FOR THE DELIVERY OF BIOLOGICALLY ACTIVE MOLECULES | SIRNA THERAPEUTICS, INC. (US) | 2008-12-04 | — | — | WO | disclosed |
| WO-2008103276-A2 | COMPOSITIONS AND METHODS FOR POTENTIATED ACTIVITY OF BIOLOGICALY ACTIVE MOLECULES | MERCK & CO., INC. (US) | 2008-08-28 | — | — | WO | disclosed |
| US-20080188675-A1 | LIPID NANOPARTICLE BASED COMPOSITIONS AND METHODS FOR THE DELIVERY OF BIOLOGICALLY ACTIVE MOLECULES | SIRNA THERAPEUTICS INC. (US) | 2008-08-07 | — | — | US | disclosed |
| US-7404969-B2 | Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules | SIRNA THERAPEUTICS, INC. (US) | 2008-07-29 | — | — | US | disclosed |
| EP-1922300-A2 | CATIONIC LIPIDS AND FORMULATED MOLECULAR COMPOSITIONS CONTAINING THEM | Sirna Therapeutics Inc. (US) | 2008-05-21 | — | — | EP | disclosed |
| US-20080020058-A1 | Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules | SIRNA THERAPEUTICS, INC. (US) | 2008-01-24 | — | — | US | disclosed |
| WO-2007086883-A2 | CATIONIC LIPIDS AND FORMULATED MOLECULAR COMPOSITIONS CONTAINING THEM | SIRNA THERAPEUTICS, INC. (US) | 2007-08-02 | — | — | WO | disclosed |
| WO-2007086881-A2 | CATIONIC LIPIDS AND FORMULATED MOLECULAR COMPOSITIONS CONTAINING THEM | SIRNA THERAPEUTICS, INC. (US) | 2007-08-02 | — | — | WO | disclosed |
| US-20060240554-A1 | Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules | SIRNA THERAPEUTICS, INC. (US) | 2006-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092739-A1 | Lipid Nanoparticle Based Compositions and Methods for the Delivery of Biologically Active Molecules | PHAX, CETP, LIPC | FDPS 825/4885MAPT 2677/4885SMN1; SMN2 1728/4885 |
| US-20090048197-A1 | Lipid Nanoparticle Based Compositions and Methods for the Delivery of Biologically Active Molecules | PHAX, CETP, LIPC | FDPS 731/4885MAPT 2625/4885SMN1; SMN2 1914/4885 |
| US-20100048888-A1 | Lipid Nanoparticle Based Compositions and Methods for the Delivery of Biologically Active Molecules | PHAX, CETP, LIPC | FDPS 731/4885MAPT 2625/4885SMN1; SMN2 1914/4885 |
| US-20100063308-A1 | LIPID NANOPARTICLE BASED COMPOSITIONS AND METHODS FOR THE DELIVERY OF BIOLOGICALLY ACTIVE MOLECULES | PHAX, CETP, LIPC | FDPS 825/4885MAPT 2677/4885SMN1; SMN2 1728/4885 |
| US-20060240554-A1 | Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules | PHAX, CETP, LIPC | FDPS 825/4885MAPT 2677/4885SMN1; SMN2 1728/4885 |
| US-20080020058-A1 | Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules | PHAX, CETP, LIPC | FDPS 731/4885MAPT 2625/4885SMN1; SMN2 1914/4885 |
| US-20100105933-A1 | LIPID NANOPARTICLE BASED COMPOSITIONS AND METHODS FOR THE DELIVERY OF BIOLOGICALLY ACTIVE MOLECULES | PHAX, CETP, LIPC | FDPS 731/4885MAPT 2625/4885SMN1; SMN2 1914/4885 |
| US-20100015218-A1 | COMPOSITIONS AND METHODS FOR POTENTIATED ACTIVITY OF BIOLOGICALLY ACTIVE MOLECULES | PHAX, MTREX, CHIA | FDPS 2638/4885MAPT 3907/4885SMN1; SMN2 2053/4885 |
| US-20080188675-A1 | LIPID NANOPARTICLE BASED COMPOSITIONS AND METHODS FOR THE DELIVERY OF BIOLOGICALLY ACTIVE MOLECULES | PHAX, CETP, LIPC | FDPS 825/4885MAPT 2677/4885SMN1; SMN2 1728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.