Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR known ✓ | P35968 | 12/20 | 0.94 |
| ▸ | FLT1 known ✓ | P17948 | 2/20 | 0.60 |
| ▸ | FLT4 known ✓ | P35916 | 1/20 | 0.60 |
| ▸ | PDGFRB known ✓ | P09619 | 1/20 | 0.48 |
| ▸ | KIT known ✓ | P10721 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 17/20 | 0.94 |
| ▸ | AXL | P30530 | 4/20 | 0.49 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1259967 | 0.97 | MET (1.00) | METKDRFLT1FLT4AXL | |
| Hydrochloric Acid SCHEMBL29363414 | 0.96 | MET (1.00) | METKDRFLT1FLT4AXL | |
| Hydrochloric Acid SCHEMBL1259611 | 0.96 | MET (1.00) | METKDRFLT1FLT4AXL | |
| Acetic Acid SCHEMBL1259628 | 0.96 | MET (0.97) | METKDRFLT1FLT4AXL | |
| SCHEMBL1259334 | 0.95 | MET (0.87) | METKDRFLT1FLT4AXL | |
| SCHEMBL1259343 | 0.92 | MET (0.90) | METKDRFLT1FLT4AXL | |
| SCHEMBL1259845 | 0.92 | MET (0.89) | METKDRFLT1FLT4AXL | |
| SCHEMBL1259492 | 0.91 | MET (0.88) | METKDRFLT1FLT4AXL | |
| Acetic Acid SCHEMBL1259623 | 0.91 | MET (0.88) | METKDRFLT1FLT4AXL | |
| Hydrochloric Acid SCHEMBL1259897 | 0.91 | MET (0.89) | METKDRFLT1FLT4AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445509-B2 | Fused heterocyclic derivatives and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-05-21 | — | — | US | disclosed |
| US-20110046169-A1 | FUSED HETEROCYCLIC DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046169-A1 | FUSED HETEROCYCLIC DERIVATIVES AND USE THEREOF | ABL1, MAP4K2, MAP3K20 | KDR 966/4885FLT1 1499/4885FLT4 1085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.