⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29088999 | 0.79 | — | — | |
| SCHEMBL7756366 | 0.71 | LMNA (0.39) | — | |
| SCHEMBL8435949 | 0.69 | TSHR (0.37) | — | |
| SCHEMBL8434166 | 0.69 | TSHR (0.37) | — | |
| SCHEMBL1744665 | 0.67 | — | — | |
| SCHEMBL8386040 | 0.65 | — | — | |
| SCHEMBL2034380 | 0.65 | — | — | |
| SCHEMBL1415181 | 0.63 | — | — | |
| SCHEMBL692687 | 0.60 | LMNA (0.42) | — | |
| SCHEMBL3363038 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108348578-A | Methods for treating myeloproliferative disorders | 阿塞勒隆制药公司 | 2018-07-31 | — | — | CN | claimed |
| CN-113286618-A | Antibody drug conjugates and uses for drug delivery of antibodies | 国立大学法人冈山大学 | 2021-08-20 | — | — | CN | disclosed |
| CN-105101979-A | Method for preparing platelets from pluripotent stem cells and composition thereof | ADVANCED CELL TECH INC | 2015-11-25 | — | — | CN | disclosed |
| US-8034905-B2 | Anti-VEGF antibody compositions and methods | Affitech Research, AS (NO) | 2011-10-11 | — | — | US | disclosed |
| US-20110189125-A1 | Modulators of HSP70/DnaK Function and Methods of Use Thereof | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2011-08-04 | — | — | US | disclosed |
| WO-2011018090-A1 | PREDICTIVE MARKER FOR HYDROXYUREA RESISTANCE | ANDERSEN STIG UGGERHOEJ (DK) | 2011-02-17 | — | — | WO | disclosed |
| WO-2011018090-A1 | PREDICTIVE MARKER FOR HYDROXYUREA RESISTANCE | ANDERSEN STIG UGGERHOEJ (DK) | 2011-02-17 | — | — | WO | disclosed |
| CN-101679313-A | AXL kinase inhibitors for the treatment of cancer or hyperproliferative diseases | SUPERGEN INC | 2010-03-24 | — | — | CN | disclosed |
| CN-101151259-A | Heteroaryl urea derivatives useful for inhibition of CHKI | ICOS CORP (US) | 2008-03-26 | — | — | CN | disclosed |
| CN-101010316-A | Compounds useful for inhibiting CHK1 | ICOS CORP (US) | 2007-08-01 | — | — | CN | disclosed |