Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.56 |
| ▸ | MAPK3 | P27361 | 3/20 | 0.54 |
| ▸ | STK17B | O94768 | 1/20 | 0.50 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.50 |
| ▸ | ALK | Q9UM73 | 9/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | INSR | P06213 | 4/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12651273 | 0.79 | STK17B (0.77) | STK17BSTK17A | |
| SCHEMBL12651671 | 0.78 | ALK (0.55) | ALKINSR | |
| SCHEMBL12609218 | 0.76 | LRRK2 (0.70) | LRRK2MAPK3STK17BSTK17AALK | |
| SCHEMBL7458726 | 0.73 | LRRK2 (1.00) | LRRK2ALKINSRIGF1RJAK2 | |
| SCHEMBL15948501 | 0.70 | MAPK3 (1.00) | MAPK3EGFR | |
| SCHEMBL10042756 | 0.69 | ALK (0.56) | LRRK2MAPK3STK17AALKEGFR | |
| SCHEMBL30879169 | 0.69 | RAB9A (0.65) | LRRK2MAPK3ALKEGFRINSR | |
| SCHEMBL13832176 | 0.68 | ALK (0.62) | ALKEGFRINSRIGF1R | |
| SCHEMBL26016229 | 0.68 | STK17B (0.46) | STK17BSTK17A | |
| SCHEMBL5670782 | 0.68 | MTNR1A (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257637-B1 | METHODS OF CHEMOTYPE EVOLUTION | SUNESIS PHARMACEUTICALS INC (US) | 2015-09-23 | — | — | EP | disclosed |
| US-20110118126-A1 | METHODS OF CHEMOTYPE EVOLUTION | SUNESIS PHARMACEUTICALS, INC. | 2011-05-19 | — | — | US | disclosed |
| WO-2009120795-A1 | METHODS OF CHEMOTYPE EVOLUTION | SUNESIS PHARMACEUTICALS, INC. (US) | 2009-10-01 | — | — | WO | disclosed |