Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | BRD2 | P25440 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17345852 | 0.87 | LMNA (0.37) | BRD4BRD2LMNAOPRM1SIGMAR1 | |
| SCHEMBL12612347 | 0.75 | — | — | |
| SCHEMBL761946 | 0.67 | GRIN1 (0.42) | BRD4BRD2POLBGRIN1GRIN2A | |
| SCHEMBL18650812 | 0.67 | LMNA (0.30) | LMNA | |
| SCHEMBL17342257 | 0.65 | PIK3CD (0.39) | — | |
| SCHEMBL20102829 | 0.64 | — | — | |
| SCHEMBL19028874 | 0.64 | — | — | |
| SCHEMBL761697 | 0.64 | — | — | |
| SCHEMBL23168692 | 0.64 | GRIN1 (0.40) | BRD4BRD2GRIN1GRIN2A | |
| SCHEMBL11224544 | 0.64 | BRD4 (0.48) | BRD4BRD2LMNAGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2686307-A1 | 1,4-OXAZEPINES AS BACE1 AND/OR BACE2 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-01-22 | — | — | EP | disclosed |
| WO-2012126791-A1 | 1,4-OXAZEPINES AS BACE1 AND/OR BACE2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-09-27 | — | — | WO | disclosed |