Sugi Predict

Sugi Predict / Compounds / SCHEMBL12627743

SCHEMBL12627743

SCHEMBL12627743

CC(C)=CC(=O)CCc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)N(C)c4cccc(Cl)c4)cc32)c(C)c1C(=O)N1CCN(C)CC1

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MET P08581 6/20 0.78
▸ KDR P35968 6/20 0.78
▸ FGFR1 P11362 4/20 0.78
▸ PTK2B Q14289 3/20 0.78
▸ MEN1 O00255 2/20 0.78
▸ CDK2 P24941 2/20 0.78
▸ KMT2A Q03164 2/20 0.78
▸ TDP1 Q9NUW8 2/20 0.78
▸ CCNE1 P24864 1/20 0.78
▸ RECQL P46063 1/20 0.78
▸ SRC P12931 9/20 0.44
▸ PDGFRB P09619 4/20 0.41
▸ LCK P06239 3/20 0.41
▸ EGFR P00533 2/20 0.41
▸ YES1 P07947 2/20 0.41
▸ ABL1 P00519 2/20 0.41
▸ CSF1R P07333 2/20 0.41
▸ RET P07949 2/20 0.41
▸ KIT P10721 2/20 0.41
▸ PHKG2 P15735 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12627746 0.89 MET (0.73) METKDRFGFR1PTK2BMEN1
SCHEMBL93711 0.88 KDR (1.00) METKDRFGFR1PTK2BMEN1
SCHEMBL93713 0.88 KDR (1.00) METKDRFGFR1PTK2BMEN1
SCHEMBL31016300 0.88 KDR (1.00) METKDRFGFR1PTK2BMEN1
SCHEMBL29394393 0.88 KDR (1.00) METKDRFGFR1PTK2BMEN1
SCHEMBL31678823 0.88 KDR (1.00) METKDRFGFR1PTK2BMEN1
SCHEMBL18999612 0.87 KDR (0.79) METKDRFGFR1PTK2BMEN1
SCHEMBL12627744 0.87 KDR (0.79) METKDRFGFR1PTK2BMEN1
SCHEMBL12627741 0.86 KDR (0.78) METKDRFGFR1PTK2BMEN1
SCHEMBL12627749 0.85 MET (0.70) METKDRFGFR1PTK2BMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10662195-B2 Protein kinase conjugates and inhibitors CELGENE CAR LLC (BM) 2020-05-26 — — US disclosed
US-20170174691-A1 Protein Kinase Conjugates and Inhibitors CELGENE CAR LLC (BM) 2017-06-22 — — US disclosed
US-20170174691-A1 Protein Kinase Conjugates and Inhibitors CELGENE CAR LLC (BM) 2017-06-22 — — US disclosed
US-9556426-B2 Protein kinase conjugates and inhibitors CELGENE AVILOMICS RESEARCH, INC. (US) 2017-01-31 — — US disclosed
US-9556426-B2 Protein kinase conjugates and inhibitors CELGENE AVILOMICS RESEARCH, INC. (US) 2017-01-31 — — US disclosed
US-20110117073-A1 Protein Kinase Conjugates and Inhibitors AVILA THERAPEUTICS, INC. (US) 2011-05-19 — — US disclosed
US-20110117073-A1 Protein Kinase Conjugates and Inhibitors AVILA THERAPEUTICS, INC. (US) 2011-05-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170174691-A1 Protein Kinase Conjugates and Inhibitors MAP3K20, ADK, TTK MET 593/4885KDR 2005/4885FGFR1 1269/4885
US-10662195-B2 Protein kinase conjugates and inhibitors MAP3K20, ADK, TTK MET 593/4885KDR 2005/4885FGFR1 1269/4885
US-20110117073-A1 Protein Kinase Conjugates and Inhibitors MAP3K20, PACSIN2, MAP3K9 MET 609/4885KDR 2212/4885FGFR1 1293/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.