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Sugi Predict / Compounds / SCHEMBL12627746

SCHEMBL12627746

SCHEMBL12627746

Cc1c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)N(C)c4cccc(Cl)c4)cc32)[nH]c(CCC(=O)C2(C#N)CC2)c1C(=O)N1CCN(C)CC1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MET P08581 6/20 0.73
▸ KDR P35968 6/20 0.73
▸ FGFR1 P11362 4/20 0.73
▸ MEN1 O00255 2/20 0.73
▸ CDK2 P24941 2/20 0.73
▸ KMT2A Q03164 2/20 0.73
▸ PTK2B Q14289 2/20 0.73
▸ TDP1 Q9NUW8 2/20 0.73
▸ CCNE1 P24864 1/20 0.73
▸ RECQL P46063 1/20 0.73
▸ SRC P12931 9/20 0.42
▸ PDGFRB P09619 4/20 0.40
▸ LCK P06239 3/20 0.40
▸ YES1 P07947 3/20 0.40
▸ EGFR P00533 2/20 0.40
▸ FLT3 P36888 2/20 0.40
▸ AURKB Q96GD4 2/20 0.40
▸ PLK4 O00444 1/20 0.40
▸ RIOK3 O14730 1/20 0.40
▸ CASK O14936 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12627743 0.89 MET (0.78) METKDRFGFR1MEN1CDK2
SCHEMBL29394393 0.85 KDR (1.00) METKDRFGFR1MEN1CDK2
SCHEMBL93711 0.85 KDR (1.00) METKDRFGFR1MEN1CDK2
SCHEMBL93713 0.85 KDR (1.00) METKDRFGFR1MEN1CDK2
SCHEMBL31678823 0.85 KDR (1.00) METKDRFGFR1MEN1CDK2
SCHEMBL31016300 0.85 KDR (1.00) METKDRFGFR1MEN1CDK2
SCHEMBL18999612 0.84 KDR (0.79) METKDRFGFR1MEN1CDK2
SCHEMBL12627744 0.84 KDR (0.79) METKDRFGFR1MEN1CDK2
SCHEMBL12627741 0.84 KDR (0.78) METKDRFGFR1MEN1CDK2
SCHEMBL12627742 0.83 KDR (0.72) METKDRFGFR1MEN1CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10662195-B2 Protein kinase conjugates and inhibitors CELGENE CAR LLC (BM) 2020-05-26 — — US disclosed
US-20170174691-A1 Protein Kinase Conjugates and Inhibitors CELGENE CAR LLC (BM) 2017-06-22 — — US disclosed
US-20170174691-A1 Protein Kinase Conjugates and Inhibitors CELGENE CAR LLC (BM) 2017-06-22 — — US disclosed
US-9556426-B2 Protein kinase conjugates and inhibitors CELGENE AVILOMICS RESEARCH, INC. (US) 2017-01-31 — — US disclosed
US-9556426-B2 Protein kinase conjugates and inhibitors CELGENE AVILOMICS RESEARCH, INC. (US) 2017-01-31 — — US disclosed
US-20110117073-A1 Protein Kinase Conjugates and Inhibitors AVILA THERAPEUTICS, INC. (US) 2011-05-19 — — US disclosed
US-20110117073-A1 Protein Kinase Conjugates and Inhibitors AVILA THERAPEUTICS, INC. (US) 2011-05-19 — — US disclosed
WO-2011034907-A2 PROTEIN KINASE CONJUGATES AND INHIBITORS AVILA THERAPEUTICS, INC. (US) 2011-03-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170174691-A1 Protein Kinase Conjugates and Inhibitors MAP3K20, ADK, TTK MET 593/4885KDR 2005/4885FGFR1 1269/4885
US-10662195-B2 Protein kinase conjugates and inhibitors MAP3K20, ADK, TTK MET 593/4885KDR 2005/4885FGFR1 1269/4885
US-20110117073-A1 Protein Kinase Conjugates and Inhibitors MAP3K20, PACSIN2, MAP3K9 MET 609/4885KDR 2212/4885FGFR1 1293/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.