Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2052027 | 1.00 | EPHX2 (0.47) | EPHX2HTTALDH1A1RAB9AKMT2A | |
| SCHEMBL12628299 | 0.91 | ALDH1A1 (0.52) | EPHX2HTTALDH1A1RAB9AKMT2A | |
| SCHEMBL2016241 | 0.91 | ALDH1A1 (0.52) | EPHX2HTTALDH1A1RAB9AKMT2A | |
| SCHEMBL12631617 | 0.84 | ALDH1A1 (0.49) | EPHX2HTTALDH1A1RAB9AKMT2A | |
| SCHEMBL12631356 | 0.83 | HTT (0.62) | HTTALDH1A1RAB9AKMT2AGAA | |
| SCHEMBL12632349 | 0.83 | NPC1 (0.58) | HTTALDH1A1RAB9AKMT2ALMNA | |
| SCHEMBL2013818 | 0.82 | ALDH1A1 (0.47) | EPHX2HTTALDH1A1RAB9AKMT2A | |
| SCHEMBL12631691 | 0.82 | ALDH1A1 (0.47) | EPHX2HTTALDH1A1RAB9AKMT2A | |
| SCHEMBL2052886 | 0.82 | NPC1 (0.49) | HTTALDH1A1RAB9AKMT2ALMNA | |
| SCHEMBL12631377 | 0.82 | NPC1 (0.49) | HTTALDH1A1RAB9AKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073277-A1 | PIPERIDINE ARYL SULFONAMIDE DERIVATIVES AS Kv1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |