Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Prochloraz. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 2/20 | 0.33 |
| ▸ | ADRB1 known ✓ | P08588 | 2/20 | 0.33 |
| ▸ | ADRB3 known ✓ | P13945 | 2/20 | 0.33 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.30 |
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.30 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.30 |
| ▸ | AHR | P35869 | 1/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.30 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prochloraz SCHEMBL2128014 | 0.94 | AHR (0.74) | AHRADRB2ADRB1ADRB3MEN1 | |
| Prochloraz SCHEMBL4745585 | 0.93 | AHR (0.85) | AHRADRB2ADRB1ADRB3MEN1 | |
| Prochloraz SCHEMBL5967411 | 0.89 | AHR (0.92) | AHRADRB2ADRB1ADRB3MEN1 | |
| Prochloraz SCHEMBL8180955 | 0.88 | AHR (0.90) | AHRADRB2ADRB1ADRB3MEN1 | |
| Prochloraz SCHEMBL9316172 | 0.88 | AHR (0.76) | AHRADRB2ADRB1ADRB3MEN1 | |
| Prochloraz SCHEMBL11296646 | 0.87 | AHR (0.85) | AHRADRB2ADRB1ADRB3MEN1 | |
| Prochloraz SCHEMBL29551185 | 0.86 | AHR (0.86) | AHRADRB2ADRB1ADRB3MEN1 | |
| Prochloraz SCHEMBL29353284 | 0.86 | AHR (0.86) | AHRADRB2ADRB1ADRB3MEN1 | |
| Prochloraz SCHEMBL5493293 | 0.86 | AHR (0.74) | AHRADRB2ADRB1ADRB3MEN1 | |
| Prochloraz SCHEMBL7381517 | 0.85 | AHR (0.85) | AHRADRB2ADRB1ADRB3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8247143-B2 | Photoreceptor, image formation method, image forming apparatus and process cartridge | RICOH COMPANY, LTD. (JP) | 2012-08-21 | — | — | US | disclosed |
| US-7879519-B2 | electrostatic latent imaging; photoconductors; charge generating layer comprises titanyl phthalocyanine pigment | RICOH COMPANY LIMITED (JP) | 2011-02-01 | — | — | US | disclosed |
| US-20100119260-A1 | PHOTORECEPTOR, IMAGE FORMATION METHOD, IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE | RICOH COMPANY, LTD. (JP) | 2010-05-13 | — | — | US | disclosed |