Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.81 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.81 |
| ▸ | ABCB1 | P08183 | 16/20 | 0.76 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Catechin Tetramethylether SCHEMBL30178011 | 1.00 | CYP3A4 (0.81) | CYP3A4MAPK1ABCB1MAPTTHRB | |
| Catechin Tetramethylether SCHEMBL28731348 | 1.00 | CYP3A4 (0.81) | CYP3A4MAPK1ABCB1MAPTTHRB | |
| Catechin Tetramethylether SCHEMBL1430853 | 1.00 | CYP3A4 (0.81) | CYP3A4MAPK1ABCB1MAPTTHRB | |
| Catechin Tetramethylether SCHEMBL30991591 | 1.00 | CYP3A4 (0.81) | CYP3A4MAPK1ABCB1MAPTTHRB | |
| SCHEMBL1973504 | 0.91 | CYP3A4 (0.80) | CYP3A4MAPK1ABCB1MAPTTHRB | |
| SCHEMBL3805650 | 0.90 | CYP3A4 (0.78) | CYP3A4MAPK1ABCB1MAPTTHRB | |
| SCHEMBL14691188 | 0.90 | CYP3A4 (0.78) | CYP3A4MAPK1ABCB1MAPTTHRB | |
| SCHEMBL25246785 | 0.88 | CYP3A4 (0.78) | CYP3A4MAPK1ABCB1MAPTTHRB | |
| SCHEMBL862416 | 0.88 | CYP3A4 (0.78) | CYP3A4MAPK1ABCB1MAPTTHRB | |
| SCHEMBL13829275 | 0.88 | CYP3A4 (0.62) | CYP3A4MAPK1ABCB1MAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9527878-B2 | Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-12-27 | — | — | US | disclosed |
| US-9527878-B2 | Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-12-27 | — | — | US | disclosed |
| US-9296717-B2 | Synthesis of C-3 coupled biflavonoids and C-3 coupled biflavonoid analogues | UNIVERSITY OF THE FREE STATE (ZA) | 2016-03-29 | — | — | US | disclosed |
| US-9296717-B2 | Synthesis of C-3 coupled biflavonoids and C-3 coupled biflavonoid analogues | UNIVERSITY OF THE FREE STATE (ZA) | 2016-03-29 | — | — | US | disclosed |
| US-20160009748-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITORS AND METHODS OF USE THEREOF TO MODULATE LIPID METABOLISM | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-01-14 | — | — | US | disclosed |
| US-20160009748-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITORS AND METHODS OF USE THEREOF TO MODULATE LIPID METABOLISM | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-01-14 | — | — | US | disclosed |
| EP-2300450-B1 | METHOD FOR THE PREPARATION OF C-4 COUPLED FLAVONOIDS, PROANTHOCYANIDINS AND ANALOGUES THEREOF | UNIV FREE STATE ZA (ZA) | 2015-12-23 | — | — | EP | disclosed |
| US-9120744-B2 | Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2015-09-01 | — | — | US | disclosed |
| US-9120744-B2 | Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2015-09-01 | — | — | US | disclosed |
| US-8501970-B2 | Method for the preparation of C-4 coupled flavonoids, proanthocyanidins and analogues thereof | UNIVERSITY OF THE FREE STATE (ZA) | 2013-08-06 | — | — | US | disclosed |
| US-20120289715-A1 | Synthesis of C-3 Coupled Biflavonoids and C-3 Coupled Biflavonoid Analogues | UNIVERSITY OF THE FREE STATE (ZA) | 2012-11-15 | — | — | US | disclosed |
| US-20120289715-A1 | Synthesis of C-3 Coupled Biflavonoids and C-3 Coupled Biflavonoid Analogues | UNIVERSITY OF THE FREE STATE (ZA) | 2012-11-15 | — | — | US | disclosed |
| US-20110160467-A1 | Method for the Preparation of C-4 Coupled Flavonoids, Proanthocyanidins and Analogues Thereof | UNIVERSITY OF THE FREE STATE (ZA) | 2011-06-30 | — | — | US | disclosed |
| US-20100137194-A1 | Plasminogen Activator Inhibitor-1 Inhibitors and Methods of Use Thereof to Modulate Lipid Metabolism | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2010-06-03 | — | — | US | disclosed |
| US-20100137194-A1 | Plasminogen Activator Inhibitor-1 Inhibitors and Methods of Use Thereof to Modulate Lipid Metabolism | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2010-06-03 | — | — | US | disclosed |
| WO-2009147645-A1 | METHOD FOR THE PREPARATION OF C-4 COUPLED FLAVONOIDS, PROANTHOCYANIDINS AND ANALOGUES THEREOF | UNIVERSITY OF THE FREE STATE (ZA) | 2009-12-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120289715-A1 | Synthesis of C-3 Coupled Biflavonoids and C-3 Coupled Biflavonoid Analogues | CBR3, C9, PROC | CYP3A4 115/4885MAPK1 1501/4885ABCB1 3877/4885 |
| US-20100137194-A1 | Plasminogen Activator Inhibitor-1 Inhibitors and Methods of Use Thereof to Modulate Lipid Metabolism | SERPINE1, PLAT, SERPINB1 | CYP3A4 1379/4885MAPK1 1437/4885ABCB1 2208/4885 |
| US-20160009748-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITORS AND METHODS OF USE THEREOF TO MODULATE LIPID METABOLISM | SERPINE1, PLAT, SERPINB1 | CYP3A4 1379/4885MAPK1 1437/4885ABCB1 2208/4885 |
| US-20110160467-A1 | Method for the Preparation of C-4 Coupled Flavonoids, Proanthocyanidins and Analogues Thereof | C9, PROC, MLN | CYP3A4 26/4885MAPK1 3038/4885ABCB1 2353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.