Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TGM2 | P21980 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | CKS1B | P61024 | 1/20 | 0.43 |
| ▸ | SKP1 | P63208 | 1/20 | 0.43 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17304702 | 0.95 | KMT2A (0.49) | CCR5KMT2AL3MBTL1KDM1AMAOB | |
| SCHEMBL28781687 | 0.91 | HSD11B1 (0.46) | CCR5KMT2AL3MBTL1KDM1AMAOB | |
| SCHEMBL19051691 | 0.91 | KMT2A (0.46) | CCR5KMT2AL3MBTL1KDM1AMAOB | |
| SCHEMBL13189171 | 0.88 | USP2 (0.54) | CCR5KMT2AL3MBTL1EPHX2BRD4 | |
| SCHEMBL4703823 | 0.87 | MEN1 (0.63) | CCR5KMT2AL3MBTL1EPHX2MEN1 | |
| SCHEMBL125088 | 0.87 | RORC (0.49) | KMT2AEPHX2HSD11B1MEN1RORC | |
| SCHEMBL13282810 | 0.79 | MMP2 (0.54) | KMT2AL3MBTL1 | |
| SCHEMBL13254806 | 0.79 | MMP2 (0.54) | KMT2AL3MBTL1 | |
| SCHEMBL5915338 | 0.78 | MEN1 (0.53) | KMT2AMEN1TGM2BRD4 | |
| SCHEMBL7698054 | 0.78 | BRD4 (0.54) | CCR5KMT2AEPHX2TGM2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111402-B1 | AMINOPYRAZOLE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2012-03-07 | — | — | EP | disclosed |
| US-7851500-B2 | Aminopyrazole kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-12-14 | — | — | US | disclosed |
| US-20100022503-A1 | AMINOPYRAZOLE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2010-01-28 | — | — | US | disclosed |
| WO-2008086128-A2 | AMINOPYRAZOLE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022503-A1 | AMINOPYRAZOLE KINASE INHIBITORS | ABL1, MAP3K19, MAP3K20 | CCR5 4274/4885KMT2A 967/4885L3MBTL1 4441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.