Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 20/20 | 0.43 |
| ▸ | HTR2A | P28223 | 18/20 | 0.43 |
| ▸ | HTR2B | P41595 | 17/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2994718 | 0.77 | HTR2C (0.56) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| SCHEMBL1181609 | 0.75 | HTR2C (0.40) | HTR2CHTR2BADRA2AADRA2BADRA2C | |
| SCHEMBL13881344 | 0.74 | PNMT (0.50) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| SCHEMBL2998073 | 0.74 | HTR2A (0.53) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| SCHEMBL12538786 | 0.71 | HTR2C (0.44) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| SCHEMBL1181171 | 0.70 | HTR2C (0.33) | HTR2CHTR2AHTR2B | |
| SCHEMBL1181211 | 0.69 | PNMT (0.43) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| SCHEMBL1181213 | 0.69 | PNMT (0.43) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| SCHEMBL5086491 | 0.64 | HTR2C (0.51) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| Lorcaserin SCHEMBL173627 | 0.62 | HTR2C (0.83) | HTR2CHTR2AHTR2BADRB1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981337-B1 | THIOPHENYL AZEPINES AS SEROTONIN 5-HT2C RECEPTOR LIGANDS AND USES THEREOF | ATHERSYS INC (US) | 2015-09-02 | — | — | EP | disclosed |
| US-20140206672-A1 | THIOPHENYL AND PYRROLYL AZEPINES AS SEROTONIN 5-HT2C RECEPTOR LIGANDS AND USES THEREOF | ABT HOLDING COMPANY (US) | 2014-07-24 | — | — | US | disclosed |
| US-20110112072-A1 | THIOPHENYL AND PYRROLYL AZEPINES AS SEROTONIN 5-HT2C RECEPTOR LIGANDS AND USES THEREOF | TUMEY L NATHAN | 2011-05-12 | — | — | US | disclosed |
| US-20110112072-A1 | THIOPHENYL AND PYRROLYL AZEPINES AS SEROTONIN 5-HT2C RECEPTOR LIGANDS AND USES THEREOF | TUMEY L NATHAN | 2011-05-12 | — | — | US | disclosed |
| US-7893051-B2 | Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof | ATHERSYS, INC. (US) | 2011-02-22 | — | — | US | disclosed |
| US-7893051-B2 | Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof | ATHERSYS, INC. (US) | 2011-02-22 | — | — | US | disclosed |
| US-20070191342-A1 | Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof | ATHERSYS, INC. | 2007-08-16 | — | — | US | disclosed |
| US-20070191342-A1 | Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof | ATHERSYS, INC. | 2007-08-16 | — | — | US | disclosed |
| WO-2007084622-A2 | THIOPHENYL AND PYRROLYL AZEPINES AS SEROTONIN 5-HT2C RECEPTOR LIGANDS AND USES THEREOF | ATHERSYS, INC. (US) | 2007-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112072-A1 | THIOPHENYL AND PYRROLYL AZEPINES AS SEROTONIN 5-HT2C RECEPTOR LIGANDS AND USES THEREOF | HTR2C, HTR5A, HTR2A | HTR2C 1/4885HTR2A 3/4885HTR2B 10/4885 |
| US-20140206672-A1 | THIOPHENYL AND PYRROLYL AZEPINES AS SEROTONIN 5-HT2C RECEPTOR LIGANDS AND USES THEREOF | HTR2C, HTR5A, HTR2A | HTR2C 1/4885HTR2A 3/4885HTR2B 10/4885 |
| US-20070191342-A1 | Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof | HTR2C, HTR5A, HTR2A | HTR2C 1/4885HTR2A 3/4885HTR2B 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.