Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 18/20 | 0.51 |
| ▸ | HTR2A | P28223 | 16/20 | 0.51 |
| ▸ | HTR2B | P41595 | 15/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.46 |
| ▸ | PNMT | P11086 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7559830 | 0.81 | MAPK1 (0.47) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| SCHEMBL3044539 | 0.78 | PNMT (0.46) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| SCHEMBL2835154 | 0.78 | PNMT (0.46) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| SCHEMBL3044542 | 0.78 | PNMT (0.46) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| SCHEMBL22458038 | 0.74 | — | — | |
| SCHEMBL22458036 | 0.74 | — | — | |
| SCHEMBL1866928 | 0.73 | GID4 (0.57) | GID4PNMT | |
| SCHEMBL3406589 | 0.73 | GID4 (0.57) | GID4PNMT | |
| SCHEMBL3404796 | 0.73 | GID4 (0.57) | GID4PNMT | |
| SCHEMBL2998073 | 0.71 | HTR2A (0.53) | HTR2CHTR2AHTR2BADRB1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981337-A2 | THIOPHENYL AND PYRROLYL AZEPINES AS SEROTONIN 5-HT2C RECEPTOR LIGANDS AND USES THEREOF | Athersys, Inc. (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007084622-A2 | THIOPHENYL AND PYRROLYL AZEPINES AS SEROTONIN 5-HT2C RECEPTOR LIGANDS AND USES THEREOF | ATHERSYS, INC. (US) | 2007-07-26 | — | — | WO | disclosed |