Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3004597 | 0.75 | PNMT (0.32) | PNMT | |
| SCHEMBL1182103 | 0.74 | HTR2C (0.33) | PNMT | |
| SCHEMBL3004504 | 0.71 | — | — | |
| SCHEMBL12636623 | 0.71 | HTR2A (0.30) | — | |
| SCHEMBL1181833 | 0.69 | ITGB3 (0.34) | PNMT | |
| SCHEMBL1181972 | 0.68 | PNMT (0.31) | PNMT | |
| SCHEMBL12872098 | 0.68 | — | — | |
| SCHEMBL1181211 | 0.61 | PNMT (0.43) | PNMT | |
| SCHEMBL1181213 | 0.61 | PNMT (0.43) | PNMT | |
| SCHEMBL12636697 | 0.58 | HTR2C (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981337-B1 | THIOPHENYL AZEPINES AS SEROTONIN 5-HT2C RECEPTOR LIGANDS AND USES THEREOF | ATHERSYS INC (US) | 2015-09-02 | — | — | EP | disclosed |
| US-20140206672-A1 | THIOPHENYL AND PYRROLYL AZEPINES AS SEROTONIN 5-HT2C RECEPTOR LIGANDS AND USES THEREOF | ABT HOLDING COMPANY (US) | 2014-07-24 | — | — | US | disclosed |
| US-20110112072-A1 | THIOPHENYL AND PYRROLYL AZEPINES AS SEROTONIN 5-HT2C RECEPTOR LIGANDS AND USES THEREOF | TUMEY L NATHAN | 2011-05-12 | — | — | US | disclosed |
| US-20110112072-A1 | THIOPHENYL AND PYRROLYL AZEPINES AS SEROTONIN 5-HT2C RECEPTOR LIGANDS AND USES THEREOF | TUMEY L NATHAN | 2011-05-12 | — | — | US | disclosed |
| US-7893051-B2 | Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof | ATHERSYS, INC. (US) | 2011-02-22 | — | — | US | disclosed |
| US-7893051-B2 | Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof | ATHERSYS, INC. (US) | 2011-02-22 | — | — | US | disclosed |
| US-20070191342-A1 | Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof | ATHERSYS, INC. | 2007-08-16 | — | — | US | disclosed |
| US-20070191342-A1 | Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof | ATHERSYS, INC. | 2007-08-16 | — | — | US | disclosed |
| WO-2007084622-A2 | THIOPHENYL AND PYRROLYL AZEPINES AS SEROTONIN 5-HT2C RECEPTOR LIGANDS AND USES THEREOF | ATHERSYS, INC. (US) | 2007-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112072-A1 | THIOPHENYL AND PYRROLYL AZEPINES AS SEROTONIN 5-HT2C RECEPTOR LIGANDS AND USES THEREOF | HTR2C, HTR5A, HTR2A | PNMT 50/4885 |
| US-20140206672-A1 | THIOPHENYL AND PYRROLYL AZEPINES AS SEROTONIN 5-HT2C RECEPTOR LIGANDS AND USES THEREOF | HTR2C, HTR5A, HTR2A | PNMT 50/4885 |
| US-20070191342-A1 | Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof | HTR2C, HTR5A, HTR2A | PNMT 50/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.