SCHEMBL126399

SCHEMBL126399

C#CCOc1ccc([NH])cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA12 O43570 6/20 0.53
▸ CA4 P22748 6/20 0.53
▸ CA9 Q16790 6/20 0.53
▸ CA1 P00915 2/20 0.53
▸ GSTP1 P09211 1/20 0.53
▸ CA2 P00918 1/20 0.53
▸ CA7 P43166 1/20 0.53
▸ MAOA P21397 8/20 0.49
▸ MAOB P27338 8/20 0.49
▸ ACHE P22303 1/20 0.49
▸ PTGS2 P35354 2/20 0.42
▸ POLB P06746 1/20 0.39
▸ MAPK1 P28482 1/20 0.39
▸ HSD17B10 Q99714 1/20 0.39
▸ KDM4E B2RXH2 1/20 0.38
▸ ALDH1A1 P00352 1/20 0.38
▸ GLA P06280 1/20 0.38
▸ GAA P10253 1/20 0.38
▸ TSHR P16473 1/20 0.38
▸ CYP1A1 P04798 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5704167 0.88 CA12 (0.63) CA12CA4CA9CA1GSTP1
Hydrochloric Acid SCHEMBL21694040 0.85 CA12 (0.61) CA12CA4CA9CA1GSTP1
SCHEMBL22388776 0.82 CA12 (0.53) CA12CA4CA9CA1GSTP1
SCHEMBL9155218 0.81 GSTP1 (0.68) CA12CA4CA9CA1GSTP1
SCHEMBL15800551 0.81 CA12 (0.57) CA12CA4CA9CA1GSTP1
SCHEMBL5684218 0.79 GSTP1 (0.60) CA12CA4CA9CA1GSTP1
SCHEMBL5981846 0.77 CA12 (0.53) CA12CA4CA9CA1GSTP1
SCHEMBL975819 0.77 CA12 (0.53) CA12CA4CA9CA1GSTP1
SCHEMBL384212 0.77 MAOB (0.56) CA12CA4CA9CA1GSTP1
SCHEMBL3805100 0.77 CA12 (0.53) CA12CA4CA9CA1GSTP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3000833-B1 MICELLES COMPRISING A TRIBLOCK COPOLYMER AND A THERAPEUTIC AGENT INTEZYNE TECH INC (US) 2019-09-04 — — EP disclosed
US-9944752-B2 Block copolymers for stable micelles INTEZYNE TECHNOLOGIES, INC. (US) 2018-04-17 — — US disclosed
US-9944754-B2 Block copolymers for stable micelles INTEZYNE TECHNOLOGIES, INC. (US) 2018-04-17 — — US disclosed
US-20170253699-A1 BLOCK COPOLYMERS FOR STABLE MICELLES INTEZYNE TECHNOLOGIES, INC. 2017-09-07 — — US disclosed
US-20170240703-A1 BLOCK COPOLYMERS FOR STABLE MICELLES INTEZYNE TECHNOLOGIES, INC. 2017-08-24 — — US disclosed
US-9499665-B2 Block copolymers for stable micelles INTEZYNE TECHNOLOGIES, INC. (US) 2016-11-22 — — US disclosed
US-20160264732-A1 BLOCK COPOLYMERS FOR STABLE MICELLES INTEZYNE TECHNOLOGIES, INC. 2016-09-15 — — US disclosed
EP-3000833-A1 BLOCK COPOLYMERS FOR STABLE MICELLES Intezyne Technologies Inc. (US) 2016-03-30 — — EP disclosed
EP-2660255-B1 Block copolymers for stable micelles INTEZYNE TECHNOLOGIES INC (US) 2015-10-28 — — EP disclosed
US-20150232616-A1 HYBRID BLOCK COPOLYMER MICELLES WITH MIXED STEREOCHEMISTRY FOR ENCAPSULATION OF HYDROPHOBIC AGENTS INTEZYNE TECHNOLOGIES, INC. 2015-08-20 — — US disclosed
EP-1907444-A2 POLYMERIC MICELLES FOR DRUG DELIVERY Intezyne Technologies Incorporated (US) 2008-04-09 — — EP disclosed
US-20080035243-A1 Covalent modification of metal surfaces INTEZYNE TECHNOLOGIES (US) 2008-02-14 — — US disclosed
WO-2008006097-A2 COVALENT MODIFICATION OF METAL SURFACES INTEZYNE TECHNOLOGIES LLC (US) 2008-01-10 — — WO disclosed
EP-1848460-A2 SYNTHESIS OF HOMOPOLYMERS AND BLOCK COPOLYMERS Intezyne Technologies Incorporated (US) 2007-10-31 — — EP disclosed
EP-1833958-A2 SYNTHESIS OF HYBRID BLOCK COPOLYMERS AND USES THEREOF Intezyne Technologies Incorporated (US) 2007-09-19 — — EP disclosed
US-20060240092-A1 drug loaded micelle of a triblock polymer tert-butylphenylsilylpropene-polyethylene glycol-b-poly(tert-butylaspartic acid-b-polyphenylalanine-copoly( tert-buyltyrosine) has a drug-loaded inner core, a crosslinked outer core, and a hydrophilic shell INTEZYNE TECHNOLOGIES, INC. 2006-10-26 — — US disclosed
WO-2006107903-A2 POLYMERIC MICELLES FOR DRUG DELIVERY INTEZYNE TECHNOLOGIES, INCORPORATED (US) 2006-10-12 — — WO disclosed
WO-2006086325-A2 SYNTHESIS OF HOMOPOLYMERS AND BLOCK COPOLYMERS INTEZYNE TECHNOLOGIES, INCORPORATED (US) 2006-08-17 — — WO disclosed
US-20060172914-A1 Synthesis of hybrid block copolymers and uses thereof INTEZYNE TECHNOLOGIES, INC. 2006-08-03 — — US disclosed
WO-2006074202-A2 SYNTHESIS OF HYBRID BLOCK COPOLYMERS AND USES THEREOF INTEZYNE TECHNOLOGIES, INCORPORATED (US) 2006-07-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080035243-A1 Covalent modification of metal surfaces ITGAL, ITGA1, ITGA5 CA12 275/4885CA4 238/4885CA9 1058/4885
US-20060240092-A1 drug loaded micelle of a triblock polymer tert-butylphenylsilylpropene-polyethylene glycol-b-poly(tert-butylaspartic acid-b-polyphenylalanine-copoly( tert-buyltyrosine) has a drug-loaded inner core, a crosslinked outer core, and a hydrophilic shell ABCB1, TERT, ABCB4 CA12 4182/4885CA4 4806/4885CA9 4499/4885
US-20160264732-A1 BLOCK COPOLYMERS FOR STABLE MICELLES ABCB4, CLTB, EPHA2 CA12 456/4885CA4 2583/4885CA9 2392/4885
US-20170240703-A1 BLOCK COPOLYMERS FOR STABLE MICELLES ABCB4, CLTB, EPHA2 CA12 456/4885CA4 2583/4885CA9 2392/4885
US-20170253699-A1 BLOCK COPOLYMERS FOR STABLE MICELLES ABCB4, CLTB, EPHA2 CA12 456/4885CA4 2583/4885CA9 2392/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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