Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 12/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5157584 | 0.79 | HSD11B1 (0.67) | HSD11B1HSD17B10L3MBTL1EPHX1EPHX2 | |
| SCHEMBL5157591 | 0.78 | HSD11B1 (0.63) | HSD11B1HSD17B10L3MBTL1EPHX2ALDH1A1 | |
| SCHEMBL4516086 | 0.76 | L3MBTL1 (0.65) | HSD11B1MAPTHSD17B10L3MBTL1EPHX1 | |
| SCHEMBL5157965 | 0.75 | HSD11B1 (0.61) | HSD11B1HSD17B10L3MBTL1EPHX1EPHX2 | |
| SCHEMBL5175433 | 0.75 | HSD11B1 (0.61) | HSD11B1HSD17B10L3MBTL1EPHX1EPHX2 | |
| SCHEMBL5160289 | 0.75 | HSD11B1 (0.68) | HSD11B1HSD17B10L3MBTL1EPHX1EPHX2 | |
| SCHEMBL6504408 | 0.74 | HSD11B1 (0.63) | HSD11B1HSD17B10L3MBTL1EPHX1EPHX2 | |
| SCHEMBL6504698 | 0.74 | HSD11B1 (0.62) | HSD11B1MAPTHSD17B10L3MBTL1EPHX1 | |
| SCHEMBL5160276 | 0.74 | HSD11B1 (0.62) | HSD11B1MAPTHSD17B10L3MBTL1EPHX1 | |
| Hydrochloric Acid SCHEMBL5154827 | 0.73 | HSD11B1 (0.70) | HSD11B1HSD17B10L3MBTL1EPHX1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871208-B2 | 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and uses thereof | ABBVIE INC. (US) | 2014-10-28 | — | — | US | disclosed |
| US-20110159005-A1 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11BETA-HSD1) INHIBITORS AND USES THEREOF | ABBOTT LABORATORIES (US) | 2011-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110159005-A1 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11BETA-HSD1) INHIBITORS AND USES THEREOF | HSD11B1, HSD17B1, HSD11B2 | HSD11B1 1/4885MAPT 3621/4885HSD17B10 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.